Eukaryotic initiation factor: Difference between revisions
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== Function == | |||
'''Eukaryotic initiation factors''' (EIF) are involved in the initiation of protein translation. They form a complex with the small subunit of the ribosome and Met-tRNA which scans the mRNA and recognizes the initiation codon AUG. EIF domains include the N terminal domain (NTD), C terminal domain (CTD), RNA recognition domain, middle domain, PAZ domain of EIF2C and a protein-protein interaction domain (PCI) of EIF3. | '''Eukaryotic initiation factors''' (EIF) are involved in the initiation of protein translation. They form a complex with the small subunit of the ribosome and Met-tRNA which scans the mRNA and recognizes the initiation codon AUG<ref>PMID:16449648</ref>. For details on EIF4 see [[C-terminal portion of human eIF4GI]]. | ||
== Disease == | |||
Overexpression of individual subunits of eIF3 may cause malignant transformation <ref>PMID:25450521</ref>. | |||
== Structural insights == | |||
EIF domains include the N terminal domain (NTD), C terminal domain (CTD), RNA recognition domain, middle domain, PAZ domain of EIF2C and a protein-protein interaction domain (PCI) of EIF3. | |||
</StructureSection> | |||
==3D structures of eukaryotic initiation factor== | ==3D structures of eukaryotic initiation factor== | ||
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**[[3j2i]] – yEIF6 + proliferation-associated protein 2G4 – cryo EM<br /> | **[[3j2i]] – yEIF6 + proliferation-associated protein 2G4 – cryo EM<br /> | ||
}} | }} | ||
== References == | |||
<references/> | |||
Revision as of 19:54, 20 January 2016
FunctionFunction
Eukaryotic initiation factors (EIF) are involved in the initiation of protein translation. They form a complex with the small subunit of the ribosome and Met-tRNA which scans the mRNA and recognizes the initiation codon AUG[1]. For details on EIF4 see C-terminal portion of human eIF4GI.
DiseaseDisease
Overexpression of individual subunits of eIF3 may cause malignant transformation [2].
Structural insightsStructural insights
EIF domains include the N terminal domain (NTD), C terminal domain (CTD), RNA recognition domain, middle domain, PAZ domain of EIF2C and a protein-protein interaction domain (PCI) of EIF3. </StructureSection>
3D structures of eukaryotic initiation factor3D structures of eukaryotic initiation factor
Updated on 20-January-2016
ReferencesReferences
- ↑ Jivotovskaya AV, Valasek L, Hinnebusch AG, Nielsen KH. Eukaryotic translation initiation factor 3 (eIF3) and eIF2 can promote mRNA binding to 40S subunits independently of eIF4G in yeast. Mol Cell Biol. 2006 Feb;26(4):1355-72. PMID:16449648 doi:http://dx.doi.org/10.1128/MCB.26.4.1355-1372.2006
- ↑ Hershey JW. The role of eIF3 and its individual subunits in cancer. Biochim Biophys Acta. 2015 Jul;1849(7):792-800. doi:, 10.1016/j.bbagrm.2014.10.005. Epub 2014 Nov 1. PMID:25450521 doi:http://dx.doi.org/10.1016/j.bbagrm.2014.10.005