1anr: Difference between revisions
New page: left|200px<br /> <applet load="1anr" size="450" color="white" frame="true" align="right" spinBox="true" caption="1anr" /> '''CIS-ACTING RNA REGULATORY ELEMENT (HIV-1 TA... |
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==About this Structure== | ==About this Structure== | ||
1ANR is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/ ]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1ANR OCA]]. | 1ANR is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/ ]]. Structure known Active Site: TAR. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1ANR OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: tat]] | [[Category: tat]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 10:57:01 2007'' | ||
Revision as of 11:52, 30 October 2007
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CIS-ACTING RNA REGULATORY ELEMENT (HIV-1 TAR), NMR, 20 STRUCTURES
OverviewOverview
Efficient transcription from the human immunodeficiency virus (HIV), promoter depends on binding of the viral regulatory protein Tat to a, cis-acting RNA regulatory element, TAR. Tat binds at a trinucleotide bulge, located near the apex of the TAR stem-loop structure. An essential feature, of Tat-TAR interaction is that the protein induces a conformational change, in TAR that repositions the functional groups on the bases and the, phosphate backbone that are critical for specific intermolecular, recognition of TAR RNA. We have previously determined a high resolution, structure for the bound form of TAR RNA using heteronuclear NMR. Here, we, describe a high resolution structure of the free TAR RNA based on 871, experimentally determined restraints. In the free TAR RNA, bulged residues, U23 ... [(full description)]
About this StructureAbout this Structure
1ANR is a [Protein complex] structure of sequences from [[1]]. Structure known Active Site: TAR. Full crystallographic information is available from [OCA].
ReferenceReference
Structure of HIV-1 TAR RNA in the absence of ligands reveals a novel conformation of the trinucleotide bulge., Aboul-ela F, Karn J, Varani G, Nucleic Acids Res. 1996 Oct 15;24(20):3974-81. PMID:8918800
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