2r6e: Difference between revisions
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|PDB= 2r6e |SIZE=350|CAPTION= <scene name='initialview01'>2r6e</scene>, resolution 5.019Å | |PDB= 2r6e |SIZE=350|CAPTION= <scene name='initialview01'>2r6e</scene>, resolution 5.019Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | |LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= DnaB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1422 Geobacillus stearothermophilus]) | |GENE= DnaB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1422 Geobacillus stearothermophilus]) | ||
|DOMAIN= | |||
|RELATEDENTRY=[[2r6a|2R6A]], [[2r6c|2R6C]], [[2r6d|2R6D]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r6e OCA], [http://www.ebi.ac.uk/pdbsum/2r6e PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2r6e RCSB]</span> | |||
}} | }} | ||
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[[Category: Eliason, W K.]] | [[Category: Eliason, W K.]] | ||
[[Category: Steitz, T A.]] | [[Category: Steitz, T A.]] | ||
[[Category: helicase]] | [[Category: helicase]] | ||
[[Category: hexameric]] | [[Category: hexameric]] | ||
[[Category: replication dnab]] | [[Category: replication dnab]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:56:57 2008'' | ||
Revision as of 04:56, 31 March 2008
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| , resolution 5.019Å | |||||||
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| Ligands: | |||||||
| Gene: | DnaB (Geobacillus stearothermophilus) | ||||||
| Related: | 2R6A, 2R6C, 2R6D
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Form B2
OverviewOverview
The complex between the DnaB helicase and the DnaG primase unwinds duplex DNA at the eubacterial replication fork and synthesizes the Okazaki RNA primers. The crystal structures of hexameric DnaB and its complex with the helicase binding domain (HBD) of DnaG reveal that within the hexamer the two domains of DnaB pack with strikingly different symmetries to form a distinct two-layered ring structure. Each of three bound HBDs stabilizes the DnaB hexamer in a conformation that may increase its processivity. Three positive, conserved electrostatic patches on the N-terminal domain of DnaB may also serve as a binding site for DNA and thereby guide the DNA to a DnaG active site.
About this StructureAbout this Structure
2R6E is a Single protein structure of sequence from Geobacillus stearothermophilus. Full crystallographic information is available from OCA.
ReferenceReference
Structure of hexameric DnaB helicase and its complex with a domain of DnaG primase., Bailey S, Eliason WK, Steitz TA, Science. 2007 Oct 19;318(5849):459-63. PMID:17947583
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