Sandbox WWC2: Difference between revisions

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+The µ-Opioid receptor
+Opioids are highly specific in function and bind to a family of receptor proteins known as the opioid receptors (OR) µ-, κ-, δ-, respectively. The µ-OR, exists in the brain, spinal cord, and in the periphery and belongs to the protein superfamily G-protein coupled receptors (GCPRs). This transmembrane protein is composed of 7 membrane-spanning alpha-helical structures in which the extracellular ligand binding pocket exists. The µ-OR crystalized is that of the Mus musculus and has been assigned the protein database (PDB) identification 4DKL. This protein was crystalized on a 2.8 Å resolution with a bound irreversible morphinan antagonist β-funaltrexamine (β-FNA) (Manglik et al., 2012). This protein was crystalyzed with the addition of a T-4 lysozyme to permit stability of the 7 TM helices by Manglik et al in 2012. Interacting residues with known ligands in the binding pocket have been determined by Cui et al in 2013, and correlate with the previously mentioned binding pocket.
 <Structure load='4dkl' size='800' frame='true' align='right' caption='''Mus musculus'' mu-OR' scene='Insert optional scene name here' />