5agq: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
''' | ==Solution structure of the TAM domain of human TIP5 BAZ2A involved in epigenetic regulation of rRNA genes== | ||
<StructureSection load='5agq' size='340' side='right' caption='[[5agq]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5agq]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AGQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AGQ FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5agq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5agq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5agq RCSB], [http://www.ebi.ac.uk/pdbsum/5agq PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[Category: | [[http://www.uniprot.org/uniprot/BAZ2A_HUMAN BAZ2A_HUMAN]] Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Anosova, I]] | |||
[[Category: Grummt, I]] | |||
[[Category: Kateb, F]] | [[Category: Kateb, F]] | ||
[[Category: Melnik, S]] | |||
[[Category: Sattler, M]] | |||
[[Category: Tripsianes, K]] | [[Category: Tripsianes, K]] | ||
[[Category: | [[Category: Epigenetic]] | ||
[[Category: | [[Category: Protein rna interaction]] | ||
[[Category: | [[Category: Rrna gene silencing]] | ||
[[Category: | [[Category: Tam domain]] | ||
[[Category: Tip5/baz2a]] | |||
[[Category: Transcription]] | |||
Revision as of 16:06, 6 May 2015
Solution structure of the TAM domain of human TIP5 BAZ2A involved in epigenetic regulation of rRNA genesSolution structure of the TAM domain of human TIP5 BAZ2A involved in epigenetic regulation of rRNA genes
Structural highlights
Function[BAZ2A_HUMAN] Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). |
| ||||||||||||||