Z-DNA: Difference between revisions

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Z-DNA binding proteins have common structural characteristics. The binding domains of these proteins can substitute one another and thus can act as competitive inhibitors against one another. As explained above, disruption in the Z-DNA binding region of E3L reduces its pathogenicity. All these observations are important pointers towards the biological importance of Z-DNA.<ref name ='Wang'>PMID:17485386</ref>
Z-DNA binding proteins have common structural characteristics. The binding domains of these proteins can substitute one another and thus can act as competitive inhibitors against one another. As explained above, disruption in the Z-DNA binding region of E3L reduces its pathogenicity. All these observations are important pointers towards the biological importance of Z-DNA.<ref name ='Wang'>PMID:17485386</ref>
</StructureSection>
</StructureSection>
__NOTOC__
== Movie Depicting ADAR1 binding to Z-DNA ==
== Movie Depicting ADAR1 binding to Z-DNA ==
<qt>file=Movie3_Z-DNA.mov|width=320|height=280|autoplay=false|controller=true</qt>
<qt>file=Movie3_Z-DNA.mov|width=320|height=280|autoplay=false|controller=true</qt>

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Adithya Sagar, Eran Hodis, Donald Voet, Karl Oberholser, David Canner, Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman