2q5u: Difference between revisions
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|PDB= 2q5u |SIZE=350|CAPTION= <scene name='initialview01'>2q5u</scene>, resolution 1.50Å | |PDB= 2q5u |SIZE=350|CAPTION= <scene name='initialview01'>2q5u</scene>, resolution 1.50Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand= | |LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY=[[1czq|1CZQ]], [[2q3i|2Q3I]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q5u OCA], [http://www.ebi.ac.uk/pdbsum/2q5u PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2q5u RCSB]</span> | |||
}} | }} | ||
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[[Category: Kim, P S.]] | [[Category: Kim, P S.]] | ||
[[Category: Malashkevich, V N.]] | [[Category: Malashkevich, V N.]] | ||
[[Category: coiled coil]] | [[Category: coiled coil]] | ||
[[Category: envelope glycoprotein]] | [[Category: envelope glycoprotein]] | ||
[[Category: viral protein/viral protein inhibitor]] | [[Category: viral protein/viral protein inhibitor]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:45:09 2008'' | ||
Revision as of 04:45, 31 March 2008
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| , resolution 1.50Å | |||||||
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| Ligands: | , | ||||||
| Related: | 1CZQ, 2Q3I
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of IQN17
OverviewOverview
The HIV-1 gp41 protein promotes viral entry by mediating the fusion of viral and cellular membranes. A prominent pocket on the surface of a central trimeric coiled coil within gp41 was previously identified as a potential target for drugs that inhibit HIV-1 entry. We designed a peptide, IQN17, which properly presents this pocket. Utilizing IQN17 and mirror-image phage display, we identified cyclic, D-peptide inhibitors of HIV-1 infection that share a sequence motif. A 1.5 A cocrystal structure of IQN17 in complex with a D-peptide, and NMR studies, show that conserved residues of these inhibitors make intimate contact with the gp41 pocket. Our studies validate the pocket per se as a target for drug development. IQN17 and these D-peptide inhibitors are likely to be useful for development and identification of a new class of orally bioavailable anti-HIV drugs.
About this StructureAbout this Structure
2Q5U is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
ReferenceReference
Inhibiting HIV-1 entry: discovery of D-peptide inhibitors that target the gp41 coiled-coil pocket., Eckert DM, Malashkevich VN, Hong LH, Carr PA, Kim PS, Cell. 1999 Oct 1;99(1):103-15. PMID:10520998
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