4xuu: Difference between revisions

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'''Unreleased structure'''
==The hSac2 domain from human phosphoinositide phosphatase Sac2==
 
<StructureSection load='4xuu' size='340' side='right' caption='[[4xuu]], [[Resolution|resolution]] 2.62&Aring;' scene=''>
The entry 4xuu is ON HOLD  until Paper Publication
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4xuu]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XUU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XUU FirstGlance]. <br>
Authors: Hsu, F., Mao, Y.
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xuu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xuu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xuu RCSB], [http://www.ebi.ac.uk/pdbsum/4xuu PDBsum]</span></td></tr>
Description: The hSac2 domain from human phosphoinositide phosphatase Sac2
</table>
[[Category: Unreleased Structures]]
== Function ==
[[http://www.uniprot.org/uniprot/SAC2_HUMAN SAC2_HUMAN]] Inositol 5-phosphatase which acts on phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Hydrolyzes phosphatidylinositol 4,5-bisphosphate most effectively. Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation.<ref>PMID:11274189</ref> <ref>PMID:17322895</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Hsu, F]]
[[Category: Mao, Y]]
[[Category: Mao, Y]]
[[Category: Hsu, F]]
[[Category: Dimerization]]
[[Category: Pleckstrin-homology domain]]
[[Category: Protein binding]]

Revision as of 17:07, 25 February 2015

The hSac2 domain from human phosphoinositide phosphatase Sac2The hSac2 domain from human phosphoinositide phosphatase Sac2

Structural highlights

4xuu is a 4 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
NonStd Res:
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[SAC2_HUMAN] Inositol 5-phosphatase which acts on phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Hydrolyzes phosphatidylinositol 4,5-bisphosphate most effectively. Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation.[1] [2]

References

  1. ↑ Minagawa T, Ijuin T, Mochizuki Y, Takenawa T. Identification and characterization of a sac domain-containing phosphoinositide 5-phosphatase. J Biol Chem. 2001 Jun 22;276(25):22011-5. Epub 2001 Mar 26. PMID:11274189 doi:http://dx.doi.org/10.1074/jbc.M101579200
  2. ↑ Trivedi CM, Luo Y, Yin Z, Zhang M, Zhu W, Wang T, Floss T, Goettlicher M, Noppinger PR, Wurst W, Ferrari VA, Abrams CS, Gruber PJ, Epstein JA. Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity. Nat Med. 2007 Mar;13(3):324-31. Epub 2007 Feb 18. PMID:17322895 doi:http://dx.doi.org/nm1552

4xuu, resolution 2.62Å

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