Tachyplesin: Difference between revisions

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Janak Raj Joshi, Shulamit Idzikowski, Michal Harel, Alexander Berchansky, Joel L. Sussman, Angel Herraez, Jaime Prilusky

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	It was found that the synthetic Tachyplesin conjugated to the integrin homing domain (RGD-Tachyplesin) can inhibit the [http://en.wikipedia.org/wiki/Cell_growth proliferation] of TSU tumor cells [http://en.wikipedia.org/wiki/Prostate_cancer prostate cancer] and B16 [http://en.wikipedia.org/wiki/Melanoma melanoma] cells as well as [http://en.wikipedia.org/wiki/Endothelium endothelial cells] in a dose-dependent manner <i>in vitro</i> and reduce tumor growth <i>in vivo</i> by inducing [http://en.wikipedia.org/wiki/Apoptosis apoptosis].<ref name=Chen>PMID:11289111‏</ref>. Besides this RGD-Tachyplesin can activate caspases and induce Fas ligand, which are the markers for programmed cell death (PCD)<ref name=Ellrby>Ellerby, H. Michael, et al. "Anti-cancer activity of targeted pro-apoptotic peptides." Nature Medicine(1999)‏</ref>.		It was found that the synthetic Tachyplesin conjugated to the integrin homing domain (RGD-Tachyplesin) can inhibit the [http://en.wikipedia.org/wiki/Cell_growth proliferation] of TSU tumor cells [http://en.wikipedia.org/wiki/Prostate_cancer prostate cancer] and B16 [http://en.wikipedia.org/wiki/Melanoma melanoma] cells as well as [http://en.wikipedia.org/wiki/Endothelium endothelial cells] in a dose-dependent manner <i>in vitro</i> and reduce tumor growth <i>in vivo</i> by inducing [http://en.wikipedia.org/wiki/Apoptosis apoptosis].<ref name=Chen>PMID:11289111‏</ref>. Besides this RGD-Tachyplesin can activate caspases and induce Fas ligand, which are the markers for programmed cell death (PCD)<ref name=Ellrby>Ellerby, H. Michael, et al. "Anti-cancer activity of targeted pro-apoptotic peptides." Nature Medicine(1999)‏</ref>.
	. Collectively, suppression of tumor associated cell and induction of programmed cell death will eventually act as therapy for cancer and tumor cells.		Collectively, suppression of tumor associated cell and induction of programmed cell death will eventually act as therapy for cancer and tumor cells.