Mycobacterium tuberculosis ArfA Rv0899: Difference between revisions
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1. Acquisition of Zn(2+) ions by {{Template:ColorKey Composition Ligand}} <scene name='61/612805/Binding-site_for_zn/1'>L82, D96, F97, H125, D127 and V129</scene> <ref>PMID: 22108166 </ref>. | 1. Acquisition of Zn(2+) ions by {{Template:ColorKey Composition Ligand}} <scene name='61/612805/Binding-site_for_zn/1'>L82, D96, F97, H125, D127 and V129</scene> <ref>PMID: 22108166 </ref>. | ||
2. Bacterium's adaptation to the acidic environment of the phagosome during infection by: | 2. Bacterium's adaptation to the acidic environment (stress response) of the phagosome during infection by: | ||
a) deamidation of the amino acid pair <scene name='61/612805/Asn111_and_gly112/1'> Asn111-Gly112 </scene>, located at the end of α1 and preceding L3, a pH-dependent reaction whereby Asn is converted to Asp and ammonia is released. Asparagine residues preceding glycine, and situated in conformationally flexible regions of proteins, are frequently deamidated, with potentially significant consequences for protein regulation and function <ref>PMID: 20199110</ref>. [[Image:Asparaginase-reaction.jpg|250px]] | a) deamidation of the amino acid pair <scene name='61/612805/Asn111_and_gly112/1'> Asn111-Gly112 </scene>, located at the end of α1 and preceding L3, a pH-dependent reaction whereby Asn is converted to Asp and ammonia is released. Asparagine residues preceding glycine, and situated in conformationally flexible regions of proteins, are frequently deamidated, with potentially significant consequences for protein regulation and function <ref>PMID: 20199110</ref>. [[Image:Asparaginase-reaction.jpg|250px]] | ||