2o39: Difference between revisions
No edit summary |
No edit summary |
||
| Line 4: | Line 4: | ||
|PDB= 2o39 |SIZE=350|CAPTION= <scene name='initialview01'>2o39</scene>, resolution 2.85Å | |PDB= 2o39 |SIZE=350|CAPTION= <scene name='initialview01'>2o39</scene>, resolution 2.85Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=CA:CALCIUM ION'>CA</scene> | |LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= PIV ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= | |GENE= PIV ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=343462 Human adenovirus 11p]), CD46, MCP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
|DOMAIN= | |||
|RELATEDENTRY=[[1ckl|1CKL]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o39 OCA], [http://www.ebi.ac.uk/pdbsum/2o39 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2o39 RCSB]</span> | |||
}} | }} | ||
| Line 14: | Line 17: | ||
==Overview== | ==Overview== | ||
Adenoviruses (Ads) are important human pathogens and valuable gene delivery vehicles. We report here the crystal structure of the species B Ad11 knob complexed with the Ad11-binding region of its receptor CD46. The conformation of bound CD46 differs profoundly from its unbound state, with the bent surface structure straightened into an elongated rod. This mechanism of interaction is likely to be conserved among many pathogens that target CD46 or related molecules. | Adenoviruses (Ads) are important human pathogens and valuable gene delivery vehicles. We report here the crystal structure of the species B Ad11 knob complexed with the Ad11-binding region of its receptor CD46. The conformation of bound CD46 differs profoundly from its unbound state, with the bent surface structure straightened into an elongated rod. This mechanism of interaction is likely to be conserved among many pathogens that target CD46 or related molecules. | ||
==About this Structure== | ==About this Structure== | ||
2O39 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/ | 2O39 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_adenovirus_11p Human adenovirus 11p]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O39 OCA]. | ||
==Reference== | ==Reference== | ||
Adenovirus type 11 binding alters the conformation of its receptor CD46., Persson BD, Reiter DM, Marttila M, Mei YF, Casasnovas JM, Arnberg N, Stehle T, Nat Struct Mol Biol. 2007 Feb;14(2):164-6. Epub 2007 Jan 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17220899 17220899] | Adenovirus type 11 binding alters the conformation of its receptor CD46., Persson BD, Reiter DM, Marttila M, Mei YF, Casasnovas JM, Arnberg N, Stehle T, Nat Struct Mol Biol. 2007 Feb;14(2):164-6. Epub 2007 Jan 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17220899 17220899] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Human adenovirus | [[Category: Human adenovirus 11p]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Arnberg, N.]] | [[Category: Arnberg, N.]] | ||
| Line 30: | Line 30: | ||
[[Category: Reiter, D M.]] | [[Category: Reiter, D M.]] | ||
[[Category: Stehle, T.]] | [[Category: Stehle, T.]] | ||
[[Category: ad11]] | [[Category: ad11]] | ||
[[Category: adenovirus]] | [[Category: adenovirus]] | ||
| Line 43: | Line 42: | ||
[[Category: virus receptor complex]] | [[Category: virus receptor complex]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:12:06 2008'' | ||