Sandbox Reserved 957: Difference between revisions
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We study here the PDE5A catalytic fragment formed of amino acid residues from the 535th to the 860th <ref>[23]</ref>. In the inhibition, we talk about the Sildenafil mostly, because it's the most known (active ingredient in the Viagra®).<br \> | We study here the PDE5A catalytic fragment formed of amino acid residues from the 535th to the 860th <ref>[23]</ref>. In the inhibition, we talk about the Sildenafil mostly, because it's the most known (active ingredient in the Viagra®).<br \> | ||
Problem in the PBD files: N-loop (from the 788th to the 881th residues) is not complete. | Problem in the PBD files: N-loop (from the 788th to the 881th residues) is not complete. | ||
qsd | |||
== Structure of catalytic site == | == Structure of catalytic site == | ||
The only catalytic fragment is effective, so the regulations sites and the dimerization to a trimeric enzyme are useless for the catalytic activity. Moreover, this catalytic moiety has the same activity that the wild-type enzyme, so maybe the enzyme is monomeric in the cell <ref>[24]</ref>. | The only catalytic fragment is effective, so the regulations sites and the dimerization to a trimeric enzyme are useless for the catalytic activity. Moreover, this catalytic moiety has the same activity that the wild-type enzyme, so maybe the enzyme is monomeric in the cell <ref>[24]</ref>. | ||