2iwr: Difference between revisions
No edit summary |
No edit summary |
||
| Line 4: | Line 4: | ||
|PDB= 2iwr |SIZE=350|CAPTION= <scene name='initialview01'>2iwr</scene>, resolution 1.50Å | |PDB= 2iwr |SIZE=350|CAPTION= <scene name='initialview01'>2iwr</scene>, resolution 1.50Å | ||
|SITE= | |SITE= | ||
|LIGAND= | |LIGAND= <scene name='pdbligand=CAF:S-DIMETHYLARSINOYL-CYSTEINE'>CAF</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY=[[2bmj|2BMJ]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iwr OCA], [http://www.ebi.ac.uk/pdbsum/2iwr PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2iwr RCSB]</span> | |||
}} | }} | ||
| Line 54: | Line 57: | ||
[[Category: zinc-finger]] | [[Category: zinc-finger]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:49:42 2008'' | ||
Revision as of 03:49, 31 March 2008
| |||||||
| , resolution 1.50Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Related: | 2BMJ
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
GTPASE LIKE DOMAIN OF CENTAURIN GAMMA 1 (HUMAN)
OverviewOverview
Centaurins are a family of proteins that contain GTPase-activating protein domains, with the gamma family members containing in addition a GTPase-like domain. Centaurins reside mainly in the nucleus and are known to activate phosphoinositide 3-kinase, a key regulator of cell proliferation, motility and vesicular trafficking. In the present study, using X-ray structural analysis, enzymatic assays and nucleotide-binding studies, we show that, for CENTG1 (centaurin gamma-1) the GTPase-like domain has broader trinucleotide specificity. Alterations within the G4 motif of CENTG1 from the highly conserved NKXD found in typical GTPases to TQDR result in the loss of specificity, a lower affinity for the nucleotides and higher turnover rates. These results indicate that the centaurins could be more accurately classified as NTPases and point to alternative mechanisms of cell signalling control.
About this StructureAbout this Structure
2IWR is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
The centaurin gamma-1 GTPase-like domain functions as an NTPase., Soundararajan M, Yang X, Elkins JM, Sobott F, Doyle DA, Biochem J. 2007 Feb 1;401(3):679-88. PMID:17037982
Page seeded by OCA on Mon Mar 31 03:49:42 2008
Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCA- Pages with broken file links
- Homo sapiens
- Single protein
- Arrowsmith, C.
- Doyle, D A.
- Edwards, A.
- Elkins, J M.
- Papagrigoriou, E.
- Sgc, Structural Genomics Consortium.
- Soundararajan, M.
- Sundstrom, M.
- Weigelt, J.
- Yang, X.
- Alternative splicing
- Ank repeat
- Centg1
- Gtp-binding
- Gtpase
- Gtpase activation
- Hydrolase
- Metal-binding
- Nuclear protein
- Nucleotide-binding
- Oncogene
- Phosphorylation
- Polymorphism
- Protein transport
- Sgc
- Structual genomics consortium
- Structural genomic
- Structural genomics consortium
- Transport
- Zinc
- Zinc-finger