Sandbox Reserved 975: Difference between revisions
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There is a negative patch surrounding the active site that is conserved between all UBCs, it is probably important in the interaction with Ubiquitin and E1, the common substrates of all UBC9s. | There is a negative patch surrounding the active site that is conserved between all UBCs, it is probably important in the interaction with Ubiquitin and E1, the common substrates of all UBC9s. | ||
But there are many particularities in the surface electric potential of UBC9, that probably reflect the specificity for E3 and the protein substrate. The electrostatic dipole is more important for UBC9 than for others UBCs. The positive charged are located on the black face of the molecule. One, for example, is located on the N-terminal region, it is composed of a segment of basic residues separated by nonpolar residues (13RKAWRK18). This positive patch is located close to the β-hairpin, the presence of those two specifities in the same region could be a sign that this site is responsible for the specificity of UBC9 for some particular E3 and protein substrates. | But there are many particularities in the surface electric potential of UBC9, that probably reflect the specificity for E3 and the protein substrate. The electrostatic dipole is more important for UBC9 than for others UBCs. The positive charged are located on the black face of the molecule. One, for example, is located on the N-terminal region, it is composed of a segment of basic residues separated by nonpolar residues (13RKAWRK18). This positive patch is located close to the <scene name='60/604494/Beta_hairpin/1'>β-hairpin</scene>, the presence of those two specifities in the same region could be a sign that this site is responsible for the specificity of UBC9 for some particular E3 and protein substrates. | ||
</StructureSection> | </StructureSection> | ||