2hwq: Difference between revisions
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|PDB= 2hwq |SIZE=350|CAPTION= <scene name='initialview01'>2hwq</scene>, resolution 1.97Å | |PDB= 2hwq |SIZE=350|CAPTION= <scene name='initialview01'>2hwq</scene>, resolution 1.97Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=DRY:[(1-{3-[(6-BENZOYL-1-PROPYL-2-NAPHTHYL)OXY]PROPYL}-1H-INDOL-5-YL)OXY]ACETIC ACID'>DRY</scene> | |LIGAND= <scene name='pdbligand=DRY:[(1-{3-[(6-BENZOYL-1-PROPYL-2-NAPHTHYL)OXY]PROPYL}-1H-INDOL-5-YL)OXY]ACETIC+ACID'>DRY</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY=[[2hwr|2HWR]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hwq OCA], [http://www.ebi.ac.uk/pdbsum/2hwq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hwq RCSB]</span> | |||
}} | }} | ||
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==Overview== | ==Overview== | ||
Type 2 diabetes has rapidly reached an epidemic proportion becoming a major threat to global public health. PPAR agonists have emerged as a leading class of oral antidiabetic drugs. We report a structure biology analysis of novel indole-based PPAR agonists to explain the structure-activity relationships and present a critical analysis of reasons for change in selectivity with change in the orientation of the same scaffolds. The results would be helpful in designing novel PPAR agonists. | Type 2 diabetes has rapidly reached an epidemic proportion becoming a major threat to global public health. PPAR agonists have emerged as a leading class of oral antidiabetic drugs. We report a structure biology analysis of novel indole-based PPAR agonists to explain the structure-activity relationships and present a critical analysis of reasons for change in selectivity with change in the orientation of the same scaffolds. The results would be helpful in designing novel PPAR agonists. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Peng, Y H.]] | [[Category: Peng, Y H.]] | ||
[[Category: Wu, S Y.]] | [[Category: Wu, S Y.]] | ||
[[Category: ligand binding protein]] | [[Category: ligand binding protein]] | ||
[[Category: ppar]] | [[Category: ppar]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:36:31 2008'' | ||
Revision as of 03:36, 31 March 2008
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| , resolution 1.97Å | |||||||
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| Ligands: | |||||||
| Related: | 2HWR
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structural basis for the structure-activity relationships of Peroxisome Proliferator-Activated Receptor agonists
OverviewOverview
Type 2 diabetes has rapidly reached an epidemic proportion becoming a major threat to global public health. PPAR agonists have emerged as a leading class of oral antidiabetic drugs. We report a structure biology analysis of novel indole-based PPAR agonists to explain the structure-activity relationships and present a critical analysis of reasons for change in selectivity with change in the orientation of the same scaffolds. The results would be helpful in designing novel PPAR agonists.
About this StructureAbout this Structure
2HWQ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists., Mahindroo N, Peng YH, Lin CH, Tan UK, Prakash E, Lien TW, Lu IL, Lee HJ, Hsu JT, Chen X, Liao CC, Lyu PC, Chao YS, Wu SY, Hsieh HP, J Med Chem. 2006 Oct 19;49(21):6421-4. PMID:17034149
Page seeded by OCA on Mon Mar 31 03:36:31 2008