4mau: Difference between revisions
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==Crystal structure of anti-ST2L antibody C2244== | ==Crystal structure of anti-ST2L antibody C2244== | ||
<StructureSection load='4mau' size='340' side='right' caption='[[4mau]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='4mau' size='340' side='right' caption='[[4mau]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
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<table><tr><td colspan='2'>[[4mau]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MAU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MAU FirstGlance]. <br> | <table><tr><td colspan='2'>[[4mau]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MAU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MAU FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mau OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mau RCSB], [http://www.ebi.ac.uk/pdbsum/4mau PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mau OCA], [http://pdbe.org/4mau PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mau RCSB], [http://www.ebi.ac.uk/pdbsum/4mau PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mau ProSAT]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4mau" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 13:48, 11 August 2016
Crystal structure of anti-ST2L antibody C2244Crystal structure of anti-ST2L antibody C2244
Structural highlights
Publication Abstract from PubMedTo assess the state-of-the-art in antibody structure modeling, a blinded study was conducted. Eleven unpublished Fab crystal structures were used as a benchmark to compare Fv models generated by seven structure prediction methodologies. In the first round, each participant submitted three non-ranked complete Fv models for each target. In the second round, CDR-H3 modeling was performed in the context of the correct environment provided by the crystal structures with CDR-H3 removed. In this report we describe the reference structures and present our assessment of the models. Some of the essential sources of errors in the predictions were traced to the selection of the structure template, both in terms of the CDR canonical structures and VL/VH packing. On top of this, the errors present in the Protein Data Bank structures were sometimes propagated in the current models, which emphasized the need for the curated structural database devoid of errors. Modeling non-canonical structures, including CDR-H3, remains the biggest challenge for antibody structure prediction. Proteins 2014. (c) 2014 Wiley Periodicals, Inc. Antibody modeling assessment II. Structures and models.,Teplyakov A, Luo J, Obmolova G, Malia TJ, Sweet R, Stanfield RL, Kodangattil S, Almagro JC, Gilliland GL Proteins. 2014 Mar 14. doi: 10.1002/prot.24554. PMID:24633955[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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