2hc4: Difference between revisions
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY=[[1db1|1DB1]], [[2hbh|2HBH]], [[2hcd|2HCD]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hc4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hc4 OCA], [http://www.ebi.ac.uk/pdbsum/2hc4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hc4 RCSB]</span> | |||
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[[Category: Moras, D.]] | [[Category: Moras, D.]] | ||
[[Category: Rochel, N.]] | [[Category: Rochel, N.]] | ||
[[Category: alpha helical sandwich]] | [[Category: alpha helical sandwich]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:28:21 2008'' | ||
Revision as of 03:28, 31 March 2008
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| , resolution 2.2Å | |||||||
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| Ligands: | |||||||
| Related: | 1DB1, 2HBH, 2HCD
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of the LBD of VDR of Danio rerio in complex with calcitriol
OverviewOverview
The crystal structure of the ligand binding domain (LBD) of the wild-type Vitamin D receptor (VDR) of zebrafish bound to Gemini, a synthetic agonist ligand with two identical side chains branching at carbon 20 reveals a ligand-dependent structural rearrangement of the ligand binding pocket (LBP). The rotation of a Leu side chain opens the access to a channel that can accommodate the second side chain of the ligand. The 25% increase of the LBP's volume does not alter the essential agonist features of VDR. The possibility to adapt the LBP to novel ligands with different chemistry and/or structure opens new perspectives in the design of more specifically targeted ligands.
About this StructureAbout this Structure
2HC4 is a Protein complex structure of sequences from Danio rerio. Full crystallographic information is available from OCA.
ReferenceReference
Adaptability of the Vitamin D nuclear receptor to the synthetic ligand Gemini: remodelling the LBP with one side chain rotation., Ciesielski F, Rochel N, Moras D, J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):235-42. Epub 2007 Jan 10. PMID:17218092
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