3rdt: Difference between revisions
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==Crystal Structure of 809.B5 TCR complexed with MHC Class II I-Ab/3k peptide== | ==Crystal Structure of 809.B5 TCR complexed with MHC Class II I-Ab/3k peptide== | ||
<StructureSection load='3rdt' size='340' side='right' caption='[[3rdt]], [[Resolution|resolution]] 2.70Å' scene=''> | <StructureSection load='3rdt' size='340' side='right' caption='[[3rdt]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3rdt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice | <table><tr><td colspan='2'>[[3rdt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RDT FirstGlance]. <br> | ||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3c60|3c60]], [[3c6l|3c6l]], [[3c5z|3c5z]], [[1lnu|1lnu]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3c60|3c60]], [[3c6l|3c6l]], [[3c5z|3c5z]], [[1lnu|1lnu]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">H2-Aa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">H2-Aa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), H2-Ab1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rdt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rdt RCSB], [http://www.ebi.ac.uk/pdbsum/3rdt PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rdt OCA], [http://pdbe.org/3rdt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3rdt RCSB], [http://www.ebi.ac.uk/pdbsum/3rdt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3rdt ProSAT]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 3rdt" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Lk3 transgenic mice]] | [[Category: Lk3 transgenic mice]] | ||
[[Category: Huseby, E S]] | [[Category: Huseby, E S]] | ||
[[Category: Stern, L J]] | [[Category: Stern, L J]] | ||
Revision as of 22:37, 11 August 2016
Crystal Structure of 809.B5 TCR complexed with MHC Class II I-Ab/3k peptideCrystal Structure of 809.B5 TCR complexed with MHC Class II I-Ab/3k peptide
Structural highlights
Publication Abstract from PubMedA limited set of T cell receptor (TCR) variable (V) gene segments are used to create a repertoire of TCRs that recognize all major histocompatibility complex (MHC) ligands within a species. How individual alphabetaTCRs are constructed to specifically recognize a limited set of MHC ligands is unclear. Here we have identified a role for the differential pairing of particular V gene segments in creating TCRs that recognized MHC class II ligands exclusively, or cross-reacted with classical and nonclassical MHC class I ligands. Biophysical and structural experiments indicated that TCR specificity for MHC ligands is not driven by germline-encoded pairwise interactions. Rather, identical TCRbeta chains can have altered peptide-MHC (pMHC) binding modes when paired with different TCRalpha chains. The ability of TCR chain pairing to modify how V region residues interact with pMHC helps to explain how the same V genes are used to create TCRs specific for unique MHC ligands. A Role for Differential Variable Gene Pairing in Creating T Cell Receptors Specific for Unique Major Histocompatibility Ligands.,Stadinski BD, Trenh P, Smith RL, Bautista B, Huseby PG, Li G, Stern LJ, Huseby ES Immunity. 2011 Nov 16. PMID:22101158[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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