Template:Homology Modeling Intro: Difference between revisions

Revision as of 21:53, 28 December 2014 view source Eric Martz (talk \| contribs) ConfirmAccount, Editor, Tester, Administrators 27,351 edits New page: ''Homology models'', also called ''comparative models'', are obtained by folding a target protein sequence to fit an empirically-determined template model. The registration between residue...		Revision as of 21:55, 28 December 2014 view source Eric Martz (talk \| contribs) ConfirmAccount, Editor, Tester, Administrators 27,351 edits No edit summary Newer edit →
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	Nevertheless, homology models are useful for seeing low-resolution features, such as which residues are on the surface or buried, which are close to other features of interest (such as a putative active site), and the overall distribution of charges and [[Evolutionary Conservation\|evolutionary conservation]].		Nevertheless, homology models are useful for seeing low-resolution features, such as which residues are on the surface or buried, which are close to other features of interest (such as a putative active site), and the overall distribution of charges and [[Evolutionary Conservation\|evolutionary conservation]].

	Attempts to improve homology models by molecular dynamics simulations have not been successful: "in most cases, simulations initiated from homology models drift away from the native structure"<ref>PMID: 22513870</ref>.