4etw: Difference between revisions
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==Structure of the Enzyme-ACP Substrate Gatekeeper Complex Required for Biotin Synthesis== | ==Structure of the Enzyme-ACP Substrate Gatekeeper Complex Required for Biotin Synthesis== | ||
<StructureSection load='4etw' size='340' side='right' caption='[[4etw]], [[Resolution|resolution]] 2.05Å' scene=''> | <StructureSection load='4etw' size='340' side='right' caption='[[4etw]], [[Resolution|resolution]] 2.05Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4etw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[4etw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"shigella_paradysenteriae"_weldin_1927 "shigella paradysenteriae" weldin 1927] and [http://en.wikipedia.org/wiki/Shif8 Shif8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ETW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ETW FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZMK:METHYL+7-{[2-({N-[(2S)-2-HYDROXY-3,3-DIMETHYL-4-(PHOSPHONOOXY)BUTANOYL]-BETA-ALANYL}AMINO)ETHYL]SULFANYL}-7-OXOHEPTANOATE'>ZMK</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZMK:METHYL+7-{[2-({N-[(2S)-2-HYDROXY-3,3-DIMETHYL-4-(PHOSPHONOOXY)BUTANOYL]-BETA-ALANYL}AMINO)ETHYL]SULFANYL}-7-OXOHEPTANOATE'>ZMK</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">bioH, SF3435, S4329 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=623 Shigella | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">bioH, SF3435, S4329 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=623 "Shigella paradysenteriae" Weldin 1927]), acpP, SFV_1114, SSON_1114 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=373384 SHIF8])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pimelyl-[acyl-carrier_protein]_methyl_ester_esterase Pimelyl-[acyl-carrier protein] methyl ester esterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.85 3.1.1.85] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pimelyl-[acyl-carrier_protein]_methyl_ester_esterase Pimelyl-[acyl-carrier protein] methyl ester esterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.85 3.1.1.85] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4etw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4etw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4etw RCSB], [http://www.ebi.ac.uk/pdbsum/4etw PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4etw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4etw OCA], [http://pdbe.org/4etw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4etw RCSB], [http://www.ebi.ac.uk/pdbsum/4etw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4etw ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/ACP_SHIF8 ACP_SHIF8]] Carrier of the growing fatty acid chain in fatty acid biosynthesis.[HAMAP-Rule:MF_01217] | [[http://www.uniprot.org/uniprot/BIOH_SHIFL BIOH_SHIFL]] The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.[HAMAP-Rule:MF_01260] [[http://www.uniprot.org/uniprot/ACP_SHIF8 ACP_SHIF8]] Carrier of the growing fatty acid chain in fatty acid biosynthesis.[HAMAP-Rule:MF_01217] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4etw" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Shigella | [[Category: Shigella paradysenteriae weldin 1927]] | ||
[[Category: | [[Category: Shif8]] | ||
[[Category: Agarwal, V]] | [[Category: Agarwal, V]] | ||
[[Category: Nair, S K]] | [[Category: Nair, S K]] | ||
[[Category: Esterase]] | [[Category: Esterase]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||