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==Crystal Structure of the bromodomain of human BAZ2B in complex with a triazolo ligand== | ==Crystal Structure of the bromodomain of human BAZ2B in complex with a triazolo ligand== | ||
<StructureSection load='3q2f' size='340' side='right' caption='[[3q2f]], [[Resolution|resolution]] 2.06Å' scene=''> | <StructureSection load='3q2f' size='340' side='right' caption='[[3q2f]], [[Resolution|resolution]] 2.06Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3q2f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3q2f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q2F FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=OAM:4-{4-[3-(1H-IMIDAZOL-1-YL)PROPYL]-5-METHYL-4H-1,2,4-TRIAZOL-3-YL}-1-METHYL-1H-PYRAZOL-5-AMINE'>OAM</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=OAM:4-{4-[3-(1H-IMIDAZOL-1-YL)PROPYL]-5-METHYL-4H-1,2,4-TRIAZOL-3-YL}-1-METHYL-1H-PYRAZOL-5-AMINE'>OAM</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3g0l|3g0l]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3g0l|3g0l]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BAZ2B, KIAA1476 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BAZ2B, KIAA1476 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q2f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q2f RCSB], [http://www.ebi.ac.uk/pdbsum/3q2f PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q2f OCA], [http://pdbe.org/3q2f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3q2f RCSB], [http://www.ebi.ac.uk/pdbsum/3q2f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3q2f ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Human]] | ||
[[Category: Arrowsmith, C H]] | [[Category: Arrowsmith, C H]] | ||
[[Category: Bountra, C]] | [[Category: Bountra, C]] | ||
Revision as of 20:22, 5 August 2016
Crystal Structure of the bromodomain of human BAZ2B in complex with a triazolo ligandCrystal Structure of the bromodomain of human BAZ2B in complex with a triazolo ligand
Structural highlights
Function[BAZ2B_HUMAN] May play a role in transcriptional regulation interacting with ISWI. |
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