2f44: Difference between revisions
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|PDB= 2f44 |SIZE=350|CAPTION= <scene name='initialview01'>2f44</scene>, resolution 2.4Å | |PDB= 2f44 |SIZE=350|CAPTION= <scene name='initialview01'>2f44</scene>, resolution 2.4Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand= | |LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= Shank3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]) | |GENE= Shank3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]) | ||
|DOMAIN= | |||
|RELATEDENTRY=[[2f3n|2F3N]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f44 OCA], [http://www.ebi.ac.uk/pdbsum/2f44 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2f44 RCSB]</span> | |||
}} | }} | ||
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[[Category: Bowie, J U.]] | [[Category: Bowie, J U.]] | ||
[[Category: Faham, S.]] | [[Category: Faham, S.]] | ||
[[Category: post-synaptic density]] | [[Category: post-synaptic density]] | ||
[[Category: sam domain]] | [[Category: sam domain]] | ||
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[[Category: zinc]] | [[Category: zinc]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:57:40 2008'' | ||
Revision as of 02:57, 31 March 2008
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| , resolution 2.4Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Gene: | Shank3 (Rattus norvegicus) | ||||||
| Related: | 2F3N
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of the Zinc-bound Shank SAM domain
OverviewOverview
The postsynaptic density (PSD) is a complex assembly of proteins associated with the postsynaptic membrane that organizes neurotransmitter receptors, signaling pathways, and regulatory elements within a cytoskeletal matrix. Here we show that the sterile alpha motif domain of rat Shank3/ProSAP2, a master scaffolding protein located deep within the PSD, can form large sheets composed of helical fibers stacked side by side. Zn2+, which is found in high concentrations in the PSD, binds tightly to Shank3 and may regulate assembly. Sheets of the Shank protein could form a platform for the construction of the PSD complex.
About this StructureAbout this Structure
2F44 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
ReferenceReference
An architectural framework that may lie at the core of the postsynaptic density., Baron MK, Boeckers TM, Vaida B, Faham S, Gingery M, Sawaya MR, Salyer D, Gundelfinger ED, Bowie JU, Science. 2006 Jan 27;311(5760):531-5. PMID:16439662
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