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==Crystal structure of human Beta-galactoside alpha-2,6-sialyltransferase 1 in complex with CMP==
==Crystal structure of human Beta-galactoside alpha-2,6-sialyltransferase 1 in complex with CMP==
<StructureSection load='4js2' size='340' side='right' caption='[[4js2]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='4js2' size='340' side='right' caption='[[4js2]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4js2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JS2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JS2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4js2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JS2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JS2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4js1|4js1]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4js1|4js1]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ST6GAL1, SIAT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ST6GAL1, SIAT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-galactoside_alpha-2,6-sialyltransferase Beta-galactoside alpha-2,6-sialyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.99.1 2.4.99.1] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-galactoside_alpha-2,6-sialyltransferase Beta-galactoside alpha-2,6-sialyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.99.1 2.4.99.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4js2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4js2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4js2 RCSB], [http://www.ebi.ac.uk/pdbsum/4js2 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4js2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4js2 OCA], [http://pdbe.org/4js2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4js2 RCSB], [http://www.ebi.ac.uk/pdbsum/4js2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4js2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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</StructureSection>
</StructureSection>
[[Category: Beta-galactoside alpha-2,6-sialyltransferase]]
[[Category: Beta-galactoside alpha-2,6-sialyltransferase]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Benz, J]]
[[Category: Benz, J]]
[[Category: Engel, A M]]
[[Category: Engel, A M]]

Revision as of 11:04, 5 August 2016

Crystal structure of human Beta-galactoside alpha-2,6-sialyltransferase 1 in complex with CMPCrystal structure of human Beta-galactoside alpha-2,6-sialyltransferase 1 in complex with CMP

Structural highlights

4js2 is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , , ,
Gene:ST6GAL1, SIAT1 (HUMAN)
Activity:Beta-galactoside alpha-2,6-sialyltransferase, with EC number 2.4.99.1
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[SIAT1_HUMAN] Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates.[1]

References

  1. ↑ Wu ZL, Ethen CM, Prather B, Machacek M, Jiang W. Universal phosphatase-coupled glycosyltransferase assay. Glycobiology. 2011 Jun;21(6):727-33. doi: 10.1093/glycob/cwq187. Epub 2010 Nov, 15. PMID:21081508 doi:10.1093/glycob/cwq187

4js2, resolution 2.30Å

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