2dq7: Difference between revisions
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|PDB= 2dq7 |SIZE=350|CAPTION= <scene name='initialview01'>2dq7</scene>, resolution 2.8Å | |PDB= 2dq7 |SIZE=350|CAPTION= <scene name='initialview01'>2dq7</scene>, resolution 2.8Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=STU:STAUROSPORINE'>STU</scene> | |LIGAND= <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene>, <scene name='pdbligand=STU:STAUROSPORINE'>STU</scene> | ||
|ACTIVITY= [http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span> | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dq7 OCA], [http://www.ebi.ac.uk/pdbsum/2dq7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2dq7 RCSB]</span> | |||
}} | }} | ||
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[[Category: Kinoshita, T.]] | [[Category: Kinoshita, T.]] | ||
[[Category: Tada, T.]] | [[Category: Tada, T.]] | ||
[[Category: kinase domain]] | [[Category: kinase domain]] | ||
[[Category: src family]] | [[Category: src family]] | ||
[[Category: staurosporine]] | [[Category: staurosporine]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:37:58 2008'' | ||
Revision as of 02:38, 31 March 2008
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| , resolution 2.8Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Activity: | Non-specific protein-tyrosine kinase, with EC number 2.7.10.2 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of Fyn kinase domain complexed with staurosporine
OverviewOverview
The tyrosine kinase Fyn is a member of the Src kinase family. Besides the role of Fyn in T cell signal transduction in concert with Lck, its excess activity in the brain is involved with conditions such as Alzheimer's and Parkinson's diseases. Therefore, inhibition of Fyn kinase may help counteract these nervous system disorders. Here, we solved the crystal structure of the human Fyn kinase domain complexed with staurosporine, a potent kinase inhibitor, at 2.8 A resolution. Staurosporine binds to the ATP-binding site of Fyn in a similar manner as in the Lck- and Csk-complexes. The small structural differences in the staurosporine-binding and/or -unbinding region among the three kinase domains may help obtaining the selective inhibitors against the respective kinases.
About this StructureAbout this Structure
2DQ7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Structure of human Fyn kinase domain complexed with staurosporine., Kinoshita T, Matsubara M, Ishiguro H, Okita K, Tada T, Biochem Biophys Res Commun. 2006 Aug 4;346(3):840-4. Epub 2006 Jun 13. PMID:16782058
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