2cdh: Difference between revisions
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cdh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdh OCA], [http://www.ebi.ac.uk/pdbsum/2cdh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2cdh RCSB]</span> | |||
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[[Category: multifunctional enzyme]] | [[Category: multifunctional enzyme]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:20:09 2008'' | ||
Revision as of 02:20, 31 March 2008
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
ARCHITECTURE OF THE THERMOMYCES LANUGINOSUS FUNGAL FATTY ACID SYNTHASE AT 5 ANGSTROM RESOLUTION.
OverviewOverview
All steps of fatty acid synthesis in fungi are catalyzed by the fatty acid synthase, which forms a 2.6-megadalton alpha6beta6 complex. We have determined the molecular architecture of this multienzyme by fitting the structures of homologous enzymes that catalyze the individual steps of the reaction pathway into a 5 angstrom x-ray crystallographic electron density map. The huge assembly contains two separated reaction chambers, each equipped with three sets of active sites separated by distances up to approximately 130 angstroms, across which acyl carrier protein shuttles substrates during the reaction cycle. Regions of the electron density arising from well-defined structural features outside the catalytic domains separate the two reaction chambers and serve as a matrix in which domains carrying the various active sites are embedded. The structure rationalizes the compartmentalization of fatty acid synthesis, and the spatial arrangement of the active sites has specific implications for our understanding of the reaction cycle mechanism and of the architecture of multienzymes in general.
About this StructureAbout this Structure
2CDH is a Single protein structure of sequence from Thermomyces lanuginosus. Full crystallographic information is available from OCA.
ReferenceReference
Architecture of a fungal fatty acid synthase at 5 A resolution., Jenni S, Leibundgut M, Maier T, Ban N, Science. 2006 Mar 3;311(5765):1263-7. PMID:16513976
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