2c6a: Difference between revisions
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|PDB= 2c6a |SIZE=350|CAPTION= <scene name='initialview01'>2c6a</scene> | |PDB= 2c6a |SIZE=350|CAPTION= <scene name='initialview01'>2c6a</scene> | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene> | |LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c6a OCA], [http://www.ebi.ac.uk/pdbsum/2c6a PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2c6a RCSB]</span> | |||
}} | }} | ||
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[[Category: Fersht, A R.]] | [[Category: Fersht, A R.]] | ||
[[Category: Yu, G W.]] | [[Category: Yu, G W.]] | ||
[[Category: alternative splicing]] | [[Category: alternative splicing]] | ||
[[Category: human mdm2]] | [[Category: human mdm2]] | ||
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[[Category: zinc finger]] | [[Category: zinc finger]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:16:56 2008'' | ||
Revision as of 02:16, 31 March 2008
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
SOLUTION STRUCTURE OF THE C4 ZINC-FINGER DOMAIN OF HDM2
OverviewOverview
HDM2 is a ubiquitin E3 ligase that is a key negative regulator of the tumor suppressor p53. Here, we report the determination of the solution structure of the C4 zinc finger domain of HDM2 using multidimensional NMR. The HDM2 C4 zinc finger domain has a fold consisting of a 3(10) helix followed by four beta-strands, which shares significant structural similarity to the zinc ribbon protein family. Family based sequence analysis identified two putative binding sites, one of which resembles an RNA binding motif.
About this StructureAbout this Structure
2C6A is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Solution structure of the C4 zinc finger domain of HDM2., Yu GW, Allen MD, Andreeva A, Fersht AR, Bycroft M, Protein Sci. 2006 Feb;15(2):384-9. Epub 2005 Dec 29. PMID:16385008
Page seeded by OCA on Mon Mar 31 02:16:56 2008