4a03: Difference between revisions
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==Crystal Structure of Mycobacterium tuberculosis DXR in complex with the antibiotic FR900098 and cofactor NADPH== | ==Crystal Structure of Mycobacterium tuberculosis DXR in complex with the antibiotic FR900098 and cofactor NADPH== | ||
<StructureSection load='4a03' size='340' side='right' caption='[[4a03]], [[Resolution|resolution]] 1.65Å' scene=''> | <StructureSection load='4a03' size='340' side='right' caption='[[4a03]], [[Resolution|resolution]] 1.65Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4a03]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[4a03]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A03 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A03 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F98:3-[ETHANOYL(HYDROXY)AMINO]PROPYLPHOSPHONIC+ACID'>F98</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F98:3-[ETHANOYL(HYDROXY)AMINO]PROPYLPHOSPHONIC+ACID'>F98</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2jcv|2jcv]], [[2jd1|2jd1]], [[2c82|2c82]], [[2y1e|2y1e]], [[2jcx|2jcx]], [[2y1c|2y1c]], [[2jcz|2jcz]], [[2jd2|2jd2]], [[2y1d|2y1d]], [[2jd0|2jd0]], [[2y1g|2y1g]], [[2jcy|2jcy]], [[2y1f|2y1f]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2jcv|2jcv]], [[2jd1|2jd1]], [[2c82|2c82]], [[2y1e|2y1e]], [[2jcx|2jcx]], [[2y1c|2y1c]], [[2jcz|2jcz]], [[2jd2|2jd2]], [[2y1d|2y1d]], [[2jd0|2jd0]], [[2y1g|2y1g]], [[2jcy|2jcy]], [[2y1f|2y1f]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-deoxy-D-xylulose-5-phosphate_reductoisomerase 1-deoxy-D-xylulose-5-phosphate reductoisomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.267 1.1.1.267] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-deoxy-D-xylulose-5-phosphate_reductoisomerase 1-deoxy-D-xylulose-5-phosphate reductoisomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.267 1.1.1.267] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a03 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a03 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a03 RCSB], [http://www.ebi.ac.uk/pdbsum/4a03 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a03 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a03 OCA], [http://pdbe.org/4a03 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4a03 RCSB], [http://www.ebi.ac.uk/pdbsum/4a03 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4a03 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4a03" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[DXP reductoisomerase|DXP reductoisomerase]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: 1-deoxy-D-xylulose-5-phosphate reductoisomerase]] | [[Category: 1-deoxy-D-xylulose-5-phosphate reductoisomerase]] | ||
[[Category: | [[Category: Myctu]] | ||
[[Category: Bergfors, T]] | [[Category: Bergfors, T]] | ||
[[Category: Bjorkelid, C]] | [[Category: Bjorkelid, C]] |