2a0x: Difference between revisions

No edit summary
No edit summary
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|PDB= 2a0x |SIZE=350|CAPTION= <scene name='initialview01'>2a0x</scene>, resolution 2.28&Aring;
|PDB= 2a0x |SIZE=350|CAPTION= <scene name='initialview01'>2a0x</scene>, resolution 2.28&Aring;
|SITE=  
|SITE=  
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=DIH:3-HYDROXY-4-HYDROXYMETHYL-1-(4-OXO-4,4A,5,7A-TETRAHYDRO-3H-PYRROLO[3,2-D]PYRIMIDIN-7-YLMETHYL)-PYRROLIDINIUM'>DIH</scene>
|LIGAND= <scene name='pdbligand=DIH:3-HYDROXY-4-HYDROXYMETHYL-1-(4-OXO-4,4A,5,7A-TETRAHYDRO-3H-PYRROLO[3,2-D]PYRIMIDIN-7-YLMETHYL)-PYRROLIDINIUM'>DIH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1]  
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] </span>
|GENE= NP, PNP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
|GENE= NP, PNP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
|DOMAIN=
|RELATEDENTRY=[[1a0w|1A0W]], [[2a0y|2A0Y]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a0x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a0x OCA], [http://www.ebi.ac.uk/pdbsum/2a0x PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2a0x RCSB]</span>
}}
}}


'''Structure of human purine nucleoside phosphorylase H257F mutant'''
'''Structure of human purine nucleoside phosphorylase H257F mutant'''


==Disease==
Known diseases associated with this structure: Neutral lipid storage disease with myopathy OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=609059 609059]], Nucleoside phosphorylase deficiency, immunodeficiency due to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164050 164050]]


==About this Structure==
==About this Structure==
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[[Category: Schramm, V L.]]
[[Category: Schramm, V L.]]
[[Category: Shi, W.]]
[[Category: Shi, W.]]
[[Category: DIH]]
[[Category: SO4]]
[[Category: mutant]]
[[Category: mutant]]
[[Category: purine nucleoside phosphorylase]]
[[Category: purine nucleoside phosphorylase]]
[[Category: transition state inhibitor]]
[[Category: transition state inhibitor]]


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