217d: Difference between revisions
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|PDB= 217d |SIZE=350|CAPTION= <scene name='initialview01'>217d</scene>, resolution 1.700Å | |PDB= 217d |SIZE=350|CAPTION= <scene name='initialview01'>217d</scene>, resolution 1.700Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=DMY:DISTAMYCIN+A'>DMY</scene> | |LIGAND= <scene name='pdbligand=C:CYTIDINE-5'-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=DC:2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DI:2'-DEOXYINOSINE-5'-MONOPHOSPHATE'>DI</scene>, <scene name='pdbligand=DMY:DISTAMYCIN+A'>DMY</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=217d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=217d OCA], [http://www.ebi.ac.uk/pdbsum/217d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=217d RCSB]</span> | |||
}} | }} | ||
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[[Category: Ramakrishnan, B.]] | [[Category: Ramakrishnan, B.]] | ||
[[Category: Sundaralingam, M.]] | [[Category: Sundaralingam, M.]] | ||
[[Category: b-dna/rna]] | [[Category: b-dna/rna]] | ||
[[Category: complexed with drug]] | [[Category: complexed with drug]] | ||
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[[Category: modified]] | [[Category: modified]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:44:20 2008'' | ||
Revision as of 01:44, 31 March 2008
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| , resolution 1.700Å | |||||||
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| Ligands: | , , , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURES OF THE B-FORM DNA-RNA CHIMER (5'-D(*IP*)-R(*CP*)-D(*IP*)-R(*CP*)-D(*IP*CP*IP*C)-3') COMPLEXED WITH DISTAMYCIN
OverviewOverview
Two DNA-RNA chimers, complexed with DNA minor groove binding drugs, have been observed to adopt the B-form conformation for the first time. Thus, the RNA duplex may assume the B-DNA conformation when interacting with drugs, peptides or proteins.
About this StructureAbout this Structure
217D is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structures of B-form DNA-RNA chimers complexed with distamycin., Chen X, Ramakrishnan B, Sundaralingam M, Nat Struct Biol. 1995 Sep;2(9):733-5. PMID:7552741
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