4x4p: Difference between revisions

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'''Unreleased structure'''
==Crystal structure of the A.fulgidus CCA-adding enzyme in complex with a G70A arginyl-tRNA minihelix ending in CCAC==
 
<StructureSection load='4x4p' size='340' side='right' caption='[[4x4p]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
The entry 4x4p is ON HOLD
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4x4p]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X4P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X4P FirstGlance]. <br>
Authors: Kuhn, C.-D., Joshua-Tor, L.
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
 
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4x4n|4x4n]], [[4x4o|4x4o]], [[4x4q|4x4q]], [[4x4r|4x4r]], [[4x4s|4x4s]], [[4x4t|4x4t]], [[4x4u|4x4u]], [[4x4v|4x4v]], [[4x4w|4x4w]], [[4x4x|4x4x]]</td></tr>
Description: Crystal structure of the A.fulgidus CCA-adding enzyme in complex with a G70A arginyl-tRNA minihelix ending in CCAC
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/CCA_tRNA_nucleotidyltransferase CCA tRNA nucleotidyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.72 2.7.7.72] </span></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x4p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4x4p RCSB], [http://www.ebi.ac.uk/pdbsum/4x4p PDBsum]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/CCA_ARCFU CCA_ARCFU]] Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.<ref>PMID:14592988</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: CCA tRNA nucleotidyltransferase]]
[[Category: Joshua-Tor, L]]
[[Category: Joshua-Tor, L]]
[[Category: Kuhn, C.-D]]
[[Category: Kuhn, C D]]
[[Category: Cca-adding enzyme]]
[[Category: Ncrna]]
[[Category: Non-coding rna]]
[[Category: Nucleotidyltransferase]]
[[Category: Protein-rna complex]]
[[Category: Rna binding protein]]
[[Category: Trna]]

Revision as of 15:05, 12 February 2015

Crystal structure of the A.fulgidus CCA-adding enzyme in complex with a G70A arginyl-tRNA minihelix ending in CCACCrystal structure of the A.fulgidus CCA-adding enzyme in complex with a G70A arginyl-tRNA minihelix ending in CCAC

Structural highlights

4x4p is a 8 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Activity:CCA tRNA nucleotidyltransferase, with EC number 2.7.7.72
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[CCA_ARCFU] Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.[1]

References

  1. ↑ Okabe M, Tomita K, Ishitani R, Ishii R, Takeuchi N, Arisaka F, Nureki O, Yokoyama S. Divergent evolutions of trinucleotide polymerization revealed by an archaeal CCA-adding enzyme structure. EMBO J. 2003 Nov 3;22(21):5918-27. PMID:14592988 doi:http://dx.doi.org/10.1093/emboj/cdg563

4x4p, resolution 3.00Å

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