4x0q: Difference between revisions

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'''Unreleased structure'''
==Ternary complex of human DNA polymerase theta C-terminal domain binding ddGTP opposite dCMP==
 
<StructureSection load='4x0q' size='340' side='right' caption='[[4x0q]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
The entry 4x0q is ON HOLD  until Paper Publication
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4x0q]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X0Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X0Q FirstGlance]. <br>
Authors: Zahn, K.E., Doublie, S.
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DG3:2-3-DIDEOXYGUANOSINE-5-TRIPHOSPHATE'>DG3</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
 
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4x0p|4x0p]]</td></tr>
Description:
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x0q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4x0q RCSB], [http://www.ebi.ac.uk/pdbsum/4x0q PDBsum]</span></td></tr>
[[Category: Zahn, K.E]]
</table>
== Function ==
[[http://www.uniprot.org/uniprot/DPOLQ_HUMAN DPOLQ_HUMAN]] Has a DNA polymerase activity on nicked double-stranded DNA and on a singly primed DNA template. The enzyme activity is resistant to aphidicolin, and inhibited by dideoxynucleotides. Exhibites a single-stranded DNA-dependent ATPase activity. Could be involved in the repair of interstrand cross-links.<ref>PMID:14576298</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: DNA-directed DNA polymerase]]
[[Category: Doublie, S]]
[[Category: Doublie, S]]
[[Category: Zahn, K E]]
[[Category: Dna polymerase]]
[[Category: Transferase-dna complex]]

Revision as of 15:16, 18 March 2015

Ternary complex of human DNA polymerase theta C-terminal domain binding ddGTP opposite dCMPTernary complex of human DNA polymerase theta C-terminal domain binding ddGTP opposite dCMP

Structural highlights

4x0q is a 6 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
Activity:DNA-directed DNA polymerase, with EC number 2.7.7.7
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[DPOLQ_HUMAN] Has a DNA polymerase activity on nicked double-stranded DNA and on a singly primed DNA template. The enzyme activity is resistant to aphidicolin, and inhibited by dideoxynucleotides. Exhibites a single-stranded DNA-dependent ATPase activity. Could be involved in the repair of interstrand cross-links.[1]

References

  1. ↑ Seki M, Marini F, Wood RD. POLQ (Pol theta), a DNA polymerase and DNA-dependent ATPase in human cells. Nucleic Acids Res. 2003 Nov 1;31(21):6117-26. PMID:14576298

4x0q, resolution 3.90Å

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