4wnw: Difference between revisions

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'''Unreleased structure'''
==Human Cytochrome P450 2D6 Thioridazine Complex==
 
<StructureSection load='4wnw' size='340' side='right' caption='[[4wnw]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
The entry 4wnw is ON HOLD  until Paper Publication
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4wnw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WNW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WNW FirstGlance]. <br>
Authors: Wang, A., Stout, C.D., Johnson, E.F.
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=RTZ:10-{2-[(2R)-1-METHYLPIPERIDIN-2-YL]ETHYL}-2-(METHYLSULFANYL)-10H-PHENOTHIAZINE'>RTZ</scene></td></tr>
 
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3qm4|3qm4]], [[3tbg|3tbg]], [[3tda|3tda]], [[2f9q|2f9q]], [[4wnv|4wnv]], [[4wnu|4wnu]], [[4wnt|4wnt]]</td></tr>
Description: Human Cytochrome P450 2D6 Thioridazine Complex
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] </span></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wnw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wnw RCSB], [http://www.ebi.ac.uk/pdbsum/4wnw PDBsum]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/CP2D6_HUMAN CP2D6_HUMAN]] Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.<ref>PMID:16352597</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Unspecific monooxygenase]]
[[Category: Johnson, E F]]
[[Category: Stout, C D]]
[[Category: Wang, A]]
[[Category: Wang, A]]
[[Category: Stout, C.D]]
[[Category: Cyp2d6]]
[[Category: Johnson, E.F]]
[[Category: Monooxygenase]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
[[Category: P450]]
[[Category: P450 2d6]]

Revision as of 16:48, 14 January 2015

Human Cytochrome P450 2D6 Thioridazine ComplexHuman Cytochrome P450 2D6 Thioridazine Complex

Structural highlights

4wnw is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , ,
Activity:Unspecific monooxygenase, with EC number 1.14.14.1
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[CP2D6_HUMAN] Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.[1]

References

  1. ↑ Rowland P, Blaney FE, Smyth MG, Jones JJ, Leydon VR, Oxbrow AK, Lewis CJ, Tennant MG, Modi S, Eggleston DS, Chenery RJ, Bridges AM. Crystal structure of human cytochrome P450 2D6. J Biol Chem. 2006 Mar 17;281(11):7614-22. Epub 2005 Dec 13. PMID:16352597 doi:http://dx.doi.org/10.1074/jbc.M511232200

4wnw, resolution 3.30Å

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