4wkf: Difference between revisions

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'''Unreleased structure'''
==Crystal structure of human chitotriosidase-1 catalytic domain in complex with chitobiose (2.5mM) at 1.10 A resolution==
 
<StructureSection load='4wkf' size='340' side='right' caption='[[4wkf]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
The entry 4wkf is ON HOLD  until Paper Publication
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4wkf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WKF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WKF FirstGlance]. <br>
Authors: Fadel, F., Zhao, Y., Cachau, R., Cousido-Siah, A., Ruiz, F.X., Harlos, K., Howard, E., Mitschler, A., Podjarny, A.
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CBS:DI(N-ACETYL-D-GLUCOSAMINE)'>CBS</scene></td></tr>
 
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>
Description: Crystal structure of human chitotriosidase-1 catalytic domain in complex with chitobiose (2.5mM) at 1.10 A resolution
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wkf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wkf RCSB], [http://www.ebi.ac.uk/pdbsum/4wkf PDBsum]</span></td></tr>
[[Category: Unreleased Structures]]
</table>
== Function ==
[[http://www.uniprot.org/uniprot/CHIT1_HUMAN CHIT1_HUMAN]] Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity.<ref>PMID:7592832</ref> <ref>PMID:7836450</ref> <ref>PMID:9748235</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Chitinase]]
[[Category: Cachau, R]]
[[Category: Cousido-Siah, A]]
[[Category: Fadel, F]]
[[Category: Fadel, F]]
[[Category: Harlos, K]]
[[Category: Howard, E]]
[[Category: Mitschler, A]]
[[Category: Podjarny, A]]
[[Category: Podjarny, A]]
[[Category: Cachau, R]]
[[Category: Ruiz, F X]]
[[Category: Mitschler, A]]
[[Category: Harlos, K]]
[[Category: Zhao, Y]]
[[Category: Zhao, Y]]
[[Category: Cousido-Siah, A]]
[[Category: Catalytic mechanism]]
[[Category: Howard, E]]
[[Category: Chit1]]
[[Category: Ruiz, F.X]]
[[Category: Gh18 chitinase]]
[[Category: Hydrolase]]
[[Category: Hydrolysis]]
[[Category: Protonation state]]

Revision as of 17:52, 8 July 2015

Crystal structure of human chitotriosidase-1 catalytic domain in complex with chitobiose (2.5mM) at 1.10 A resolutionCrystal structure of human chitotriosidase-1 catalytic domain in complex with chitobiose (2.5mM) at 1.10 A resolution

Structural highlights

4wkf is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Activity:Chitinase, with EC number 3.2.1.14
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[CHIT1_HUMAN] Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity.[1] [2] [3]

References

  1. ↑ Boot RG, Renkema GH, Strijland A, van Zonneveld AJ, Aerts JM. Cloning of a cDNA encoding chitotriosidase, a human chitinase produced by macrophages. J Biol Chem. 1995 Nov 3;270(44):26252-6. PMID:7592832
  2. ↑ Renkema GH, Boot RG, Muijsers AO, Donker-Koopman WE, Aerts JM. Purification and characterization of human chitotriosidase, a novel member of the chitinase family of proteins. J Biol Chem. 1995 Feb 3;270(5):2198-202. PMID:7836450
  3. ↑ Boot RG, Renkema GH, Verhoek M, Strijland A, Bliek J, de Meulemeester TM, Mannens MM, Aerts JM. The human chitotriosidase gene. Nature of inherited enzyme deficiency. J Biol Chem. 1998 Oct 2;273(40):25680-5. PMID:9748235

4wkf, resolution 1.10Å

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