1yv3: Difference between revisions

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The structural basis of blebbistatin inhibition and specificity for myosin II

OverviewOverview

Molecular motors play a central role in cytoskeletal-mediated cellular processes and thus present an excellent target for cellular control by pharmacological agents. Yet very few such compounds have been found. We report here the structure of blebbistatin, which inhibits specific myosin isoforms, bound to the motor domain of Dictyostelium discoideum myosin II. This reveals the structural basis for its specificity and provides insight into the development of new agents.

About this StructureAbout this Structure

1YV3 is a Single protein structure of sequence from Dictyostelium discoideum. Full crystallographic information is available from OCA.

ReferenceReference

The structural basis of blebbistatin inhibition and specificity for myosin II., Allingham JS, Smith R, Rayment I, Nat Struct Mol Biol. 2005 Apr;12(4):378-9. Epub 2005 Mar 6. PMID:15750603

Page seeded by OCA on Sun Mar 23 14:24:14 2008

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OCA

@@ Line 4: / Line 4: @@
 |PDB= 1yv3 |SIZE=350|CAPTION= <scene name='initialview01'>1yv3</scene>, resolution 2.0&Aring;
 |SITE=
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+|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene>, <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BIT:(-)-1-PHENYL-1,2,3,4-TETRAHYDRO-4-HYDROXYPYRROLO[2,3-B]-7-METHYLQUINOLIN-4-ONE'>BIT</scene> and <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>
 |ACTIVITY=
 |GENE=
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 [[Category: myosin-inhibitor complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:27:56 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 14:24:14 2008''