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==Crystal structure of ternary complex of Plasmodium vivax SHMT with glycine and a novel pyrazolopyran 33G: (4S)-6-amino-4-(5-cyano-3'-fluorobiphenyl-3-yl)-4-cyclobutyl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile== | |||
<StructureSection load='4tn4' size='340' side='right' caption='[[4tn4]], [[Resolution|resolution]] 2.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4tn4]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TN4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TN4 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=33G:(4S)-6-AMINO-4-(5-CYANO-3-FLUOROBIPHENYL-3-YL)-4-CYCLOBUTYL-3-METHYL-2,4-DIHYDROPYRANO[2,3-C]PYRAZOLE-5-CARBONITRILE'>33G</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PLG:N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE]'>PLG</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4pff|4pff]], [[4pfn|4pfn]], [[4oyt|4oyt]], [[4o6z|4o6z]], [[4tmr|4tmr]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tn4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tn4 RCSB], [http://www.ebi.ac.uk/pdbsum/4tn4 PDBsum]</span></td></tr> | |||
[[Category: | </table> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Chitnumsub, P]] | |||
[[Category: Jaruwat, A]] | [[Category: Jaruwat, A]] | ||
[[Category: Leartsakulpanich, U]] | [[Category: Leartsakulpanich, U]] | ||
[[Category: Witschel, M | [[Category: Witschel, M C]] | ||
[[Category: | [[Category: Alpha and beta protein]] | ||
[[Category: Inhibitor]] | |||
[[Category: Methyltransferase activity]] | |||
[[Category: Transferase]] | |||
[[Category: Transferase-transferase inhibitor complex]] | |||
Revision as of 17:11, 26 March 2015
Crystal structure of ternary complex of Plasmodium vivax SHMT with glycine and a novel pyrazolopyran 33G: (4S)-6-amino-4-(5-cyano-3'-fluorobiphenyl-3-yl)-4-cyclobutyl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrileCrystal structure of ternary complex of Plasmodium vivax SHMT with glycine and a novel pyrazolopyran 33G: (4S)-6-amino-4-(5-cyano-3'-fluorobiphenyl-3-yl)-4-cyclobutyl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
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