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'''Unreleased structure'''
==Crystal Structure of Murine H90W Cyclooxygenase-2 Complexed with S-ibuprofen==
 
<StructureSection load='4rs0' size='340' side='right' caption='[[4rs0]], [[Resolution|resolution]] 2.81&Aring;' scene=''>
The entry 4rs0 is ON HOLD  until Paper Publication
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4rs0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RS0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RS0 FirstGlance]. <br>
Authors: Xu, S., Blobaum, A.L., Banerjee, S., Marnett, L.J.
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=IBP:IBUPROFEN'>IBP</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
 
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4rrw|4rrw]], [[4rrx|4rrx]], [[4rry|4rry]], [[4rrz|4rrz]]</td></tr>
Description: Crystal Structure of Murine H90W Cyclooxygenase-2 Complexed with S-ibuprofen
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] </span></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rs0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rs0 RCSB], [http://www.ebi.ac.uk/pdbsum/4rs0 PDBsum]</span></td></tr>
[[Category: Blobaum, A.L]]
</table>
== Function ==
[[http://www.uniprot.org/uniprot/PGH2_MOUSE PGH2_MOUSE]] Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.<ref>PMID:12925531</ref> <ref>PMID:20463020</ref> <ref>PMID:20810665</ref> <ref>PMID:21489986</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Prostaglandin-endoperoxide synthase]]
[[Category: Banerjee, S]]
[[Category: Blobaum, A L]]
[[Category: Marnett, L J]]
[[Category: Xu, S]]
[[Category: Xu, S]]
[[Category: Banerjee, S]]
[[Category: Glycosylation]]
[[Category: Marnett, L.J]]
[[Category: Membrane]]
[[Category: Nsaid]]
[[Category: Oxidoreductase]]
[[Category: Protein-drug complex]]

Revision as of 14:14, 8 April 2015

Crystal Structure of Murine H90W Cyclooxygenase-2 Complexed with S-ibuprofenCrystal Structure of Murine H90W Cyclooxygenase-2 Complexed with S-ibuprofen

Structural highlights

4rs0 is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
Activity:Prostaglandin-endoperoxide synthase, with EC number 1.14.99.1
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[PGH2_MOUSE] Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.[1] [2] [3] [4]

References

  1. ↑ Rowlinson SW, Kiefer JR, Prusakiewicz JJ, Pawlitz JL, Kozak KR, Kalgutkar AS, Stallings WC, Kurumbail RG, Marnett LJ. A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385. J Biol Chem. 2003 Nov 14;278(46):45763-9. Epub 2003 Aug 18. PMID:12925531 doi:http://dx.doi.org/10.1074/jbc.M305481200
  2. ↑ Vecchio AJ, Simmons DM, Malkowski MG. Structural basis of fatty acid substrate binding to cyclooxygenase-2. J Biol Chem. 2010 Jul 16;285(29):22152-63. Epub 2010 May 12. PMID:20463020 doi:10.1074/jbc.M110.119867
  3. ↑ Duggan KC, Walters MJ, Musee J, Harp JM, Kiefer JR, Oates JA, Marnett LJ. Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen. J Biol Chem. 2010 Nov 5;285(45):34950-9. Epub 2010 Sep 1. PMID:20810665 doi:10.1074/jbc.M110.162982
  4. ↑ Vecchio AJ, Malkowski MG. The structural basis of endocannabinoid oxygenation by cyclooxygenase-2. J Biol Chem. 2011 Jun 10;286(23):20736-45. Epub 2011 Apr 13. PMID:21489986 doi:10.1074/jbc.M111.230367

4rs0, resolution 2.81Å

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