4pvf: Difference between revisions

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-'''Unreleased structure'''
+==Crystal structure of Homo sapiens holo serine hydroxymethyltransferase 2 (mitochondrial) (SHMT2), isoform 3, transcript variant 5, 483 aa, at 2.6 ang. resolution==
+<StructureSection load='4pvf' size='340' side='right' caption='[[4pvf]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-The entry 4pvf is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4pvf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PVF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PVF FirstGlance]. <br>
-Authors: Giardina, G., Brunotti, P., Fiascarelli, A., Contestabile, R., Cutruzzola, F.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE)'>LLP</scene></td></tr>
-Description: Crystal structure of Homo sapiens holo serine hydroxymethyltransferase 2 (mitochondrial) (SHMT2), isoform 3, transcript variant 5, 483 aa, at 2.6 ang. resolution
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine_hydroxymethyltransferase Glycine hydroxymethyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.1 2.1.2.1] </span></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pvf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pvf RCSB], [http://www.ebi.ac.uk/pdbsum/4pvf PDBsum]</span></td></tr>
-[[Category: Cutruzzola, F]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/GLYM_HUMAN GLYM_HUMAN]] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA.<ref>PMID:21876188</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Glycine hydroxymethyltransferase]]
 [[Category: Brunotti, P]]
 [[Category: Contestabile, R]]
+[[Category: Cutruzzola, F]]
 [[Category: Fiascarelli, A]]
 [[Category: Giardina, G]]
+[[Category: 5-formyl-thf]]
+[[Category: Aat-like fold]]
+[[Category: Hydroxymethyltransferase]]
+[[Category: Methylase]]
+[[Category: Mitochondrial]]
+[[Category: One carbon metabolism]]
+[[Category: Transferase]]