4ooq: Difference between revisions

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'''Unreleased structure'''
==apo-dUTPase from Arabidopsis thaliana==
 
<StructureSection load='4ooq' size='340' side='right' caption='[[4ooq]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
The entry 4ooq is ON HOLD  until Paper Publication
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4ooq]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OOQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OOQ FirstGlance]. <br>
Authors: Inoguchi, N., Bajaj, M., Moriyama, H.
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
 
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4oop|4oop]]</td></tr>
Description: apo-dUTPase from Arabidopsis thaliana
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] </span></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ooq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ooq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ooq RCSB], [http://www.ebi.ac.uk/pdbsum/4ooq PDBsum]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/DUT_ARATH DUT_ARATH]] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP, preventing uracil incorporation into DNA.<ref>PMID:20227352</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: DUTP diphosphatase]]
[[Category: Bajaj, M]]
[[Category: Inoguchi, N]]
[[Category: Moriyama, H]]
[[Category: Moriyama, H]]
[[Category: Inoguchi, N]]
[[Category: Dutp]]
[[Category: Bajaj, M]]
[[Category: Dutpase]]
[[Category: Hydrolase]]
[[Category: Hydrolysis]]

Revision as of 17:12, 22 July 2015

apo-dUTPase from Arabidopsis thalianaapo-dUTPase from Arabidopsis thaliana

Structural highlights

4ooq is a 3 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Activity:dUTP diphosphatase, with EC number 3.6.1.23
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[DUT_ARATH] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP, preventing uracil incorporation into DNA.[1]

References

  1. ↑ Siaud N, Dubois E, Massot S, Richaud A, Dray E, Collier J, Doutriaux MP. The SOS screen in Arabidopsis: a search for functions involved in DNA metabolism. DNA Repair (Amst). 2010 May 4;9(5):567-78. doi: 10.1016/j.dnarep.2010.02.009., Epub 2010 Mar 12. PMID:20227352 doi:http://dx.doi.org/10.1016/j.dnarep.2010.02.009

4ooq, resolution 2.00Å

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OCA
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