4ogu: Difference between revisions

← Older edit Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates==
+<StructureSection load='4ogu' size='340' side='right' caption='[[4ogu]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-The entry 4ogu is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4ogu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OGU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OGU FirstGlance]. <br>
-Authors: Tsoumpra, M.K., Barnett, B.L., Muniz, J.R.C., Walter, R.L., Ebetino, F.H., Von Delft, F., Russell, R.G.G., Oppermann, U., Dunford, J.E.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=210:PAMIDRONATE'>210</scene>, <scene name='pdbligand=IPE:3-METHYLBUT-3-ENYL+TRIHYDROGEN+DIPHOSPHATE'>IPE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4n9u|4n9u]], [[4ng6|4ng6]], [[1zw5|1zw5]], [[4nua|4nua]]</td></tr>
-Description: The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ogu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ogu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ogu RCSB], [http://www.ebi.ac.uk/pdbsum/4ogu PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
+__TOC__
+</StructureSection>
+[[Category: Barnett, B L]]
+[[Category: Delft, F Von]]
+[[Category: Dunford, J E]]
+[[Category: Ebetino, F H]]
+[[Category: Muniz, J R.C]]
 [[Category: Oppermann, U]]
-[[Category: Barnett, B.L]]
+[[Category: Russell, R G.G]]
-[[Category: Russell, R.G.G]]
+[[Category: Tsoumpra, M K]]
-[[Category: Dunford, J.E]]
+[[Category: Walter, R L]]
-[[Category: Von Delft, F]]
+[[Category: All alpha-helical]]
-[[Category: Walter, R.L]]
+[[Category: Cholesterol synthesis]]
-[[Category: Tsoumpra, M.K]]
+[[Category: Isoprene biosynthesis]]
-[[Category: Muniz, J.R.C]]
+[[Category: Isoprenoid pathway]]
-[[Category: Ebetino, F.H]]
+[[Category: Lipid biosynthesis]]
+[[Category: Prenyltransferase]]
+[[Category: Steroid biosynthesis]]
+[[Category: Transferase]]