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''' | ==Crystal structure of human FPPS in complex with magnesium and JDS05120== | ||
<StructureSection load='4nfi' size='340' side='right' caption='[[4nfi]], [[Resolution|resolution]] 1.85Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4nfi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NFI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NFI FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JD5:[({5-[4-(CYCLOPROPYLOXY)PHENYL]PYRIDIN-3-YL}AMINO)METHANEDIYL]BIS(PHOSPHONIC+ACID)'>JD5</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4nfj|4nfj]], [[4nfk|4nfk]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nfi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nfi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nfi RCSB], [http://www.ebi.ac.uk/pdbsum/4nfi PDBsum]</span></td></tr> | |||
[[ | </table> | ||
[[Category: | == Function == | ||
[[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Berghuis, A M]] | |||
[[Category: Park, J]] | [[Category: Park, J]] | ||
[[Category: | [[Category: Schutter, J W.De]] | ||
[[Category: Tsantrizos, Y | [[Category: Tsantrizos, Y S]] | ||
[[Category: Transferase-transferase inhibitor complex]] | |||
Revision as of 17:50, 31 December 2014
Crystal structure of human FPPS in complex with magnesium and JDS05120Crystal structure of human FPPS in complex with magnesium and JDS05120
Structural highlights
Function[FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. |
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