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''' | ==Human beta-tryptase co-crystal structure with (2R,4S)-N,N'-bis[3-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)phenyl]-4-hydroxy-2-(2-hydroxypropan-2-yl)-5,5-dimethyl-1,3-dioxolane-2,4-dicarboxamide== | ||
<StructureSection load='4mpv' size='340' side='right' caption='[[4mpv]], [[Resolution|resolution]] 2.31Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4mpv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MPV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MPV FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2A4:(2R,4S)-N,N-BIS[3-({4-[3-(AMINOMETHYL)PHENYL]PIPERIDIN-1-YL}CARBONYL)PHENYL]-4-HYDROXY-2-(2-HYDROXYPROPAN-2-YL)-5,5-DIMETHYL-1,3-DIOXOLANE-2,4-DICARBOXAMIDE'>2A4</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4mpu|4mpu]], [[4mpw|4mpw]], [[4mpx|4mpx]], [[4mqa|4mqa]]</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptase Tryptase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.59 3.4.21.59] </span></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mpv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mpv RCSB], [http://www.ebi.ac.uk/pdbsum/4mpv PDBsum]</span></td></tr> | ||
[[Category: Stein, A | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/TRYB1_HUMAN TRYB1_HUMAN]] Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Tryptase]] | |||
[[Category: Stein, A J]] | |||
[[Category: Suto, R]] | |||
[[Category: White, A]] | [[Category: White, A]] | ||
[[Category: | [[Category: Alpha-hydroxyketone]] | ||
[[Category: Coferon]] | |||
[[Category: Crystal catalysis]] | |||
[[Category: Drug discovery]] | |||
[[Category: Hydrolase-hydrolase inhibitor complex]] | |||
[[Category: Self-assembly]] | |||
[[Category: Small molecule inhibitor]] | |||
Revision as of 15:10, 18 March 2015
Human beta-tryptase co-crystal structure with (2R,4S)-N,N'-bis[3-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)phenyl]-4-hydroxy-2-(2-hydroxypropan-2-yl)-5,5-dimethyl-1,3-dioxolane-2,4-dicarboxamideHuman beta-tryptase co-crystal structure with (2R,4S)-N,N'-bis[3-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)phenyl]-4-hydroxy-2-(2-hydroxypropan-2-yl)-5,5-dimethyl-1,3-dioxolane-2,4-dicarboxamide
Structural highlights
Function[TRYB1_HUMAN] Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type (By similarity). |
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