4mpu: Difference between revisions

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-'''Unreleased structure'''
+==Human beta-tryptase co-crystal structure with (6S,8R)-N,N'-bis[3-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)phenyl]-8-hydroxy-6-(1-hydroxycyclobutyl)-5,7-dioxaspiro[3.4]octane-6,8-dicarboxamide==
+<StructureSection load='4mpu' size='340' side='right' caption='[[4mpu]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
-The entry 4mpu is ON HOLD  until Mar 18 2016
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4mpu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MPU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MPU FirstGlance]. <br>
-Authors: White, A., Stein, A.J., Suto, R.K.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=X2A:(6S,8R)-N,N-BIS[3-({4-[3-(AMINOMETHYL)PHENYL]PIPERIDIN-1-YL}CARBONYL)PHENYL]-8-HYDROXY-6-(1-HYDROXYCYCLOBUTYL)-5,7-DIOXASPIRO[3.4]OCTANE-6,8-DICARBOXAMIDE'>X2A</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4mpv|4mpv]], [[4mpw|4mpw]], [[4mpx|4mpx]], [[4mqa|4mqa]]</td></tr>
-Description:
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptase Tryptase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.59 3.4.21.59] </span></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mpu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mpu RCSB], [http://www.ebi.ac.uk/pdbsum/4mpu PDBsum]</span></td></tr>
-[[Category: Suto, R.K]]
+</table>
-[[Category: Stein, A.J]]
+== Function ==
+[[http://www.uniprot.org/uniprot/TRYB1_HUMAN TRYB1_HUMAN]] Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type (By similarity).
+__TOC__
+</StructureSection>
+[[Category: Tryptase]]
+[[Category: Stein, A J]]
+[[Category: Suto, R K]]
 [[Category: White, A]]
+[[Category: Alpha-hydroxyketone]]
+[[Category: Coferon]]
+[[Category: Crystal catalysis]]
+[[Category: Drug discovery]]
+[[Category: Hydrolase-hydrolase inhibitor complex]]
+[[Category: Self-assembly]]
+[[Category: Small molecule inhibitor]]