1a8b: Difference between revisions

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RAT ANNEXIN V COMPLEXED WITH GLYCEROPHOSPHOETHANOLAMINE

OverviewOverview

Structural evidence is presented for a 'Ca(2+)-bridging' mechanism, proposed for Ca(2+)-binding interfacial membrane proteins such as, annexins, protein kinase C, and certain coagulation proteins. Crystal, structures of Ca(2+)-annexin V complexes with phospholipid polar heads, provide molecular details of 'Ca(2+)-bridges' as key features in the, membrane attachment exhibited by these proteins. Distinct binding sites, for phospholipid head groups are observed, including a novel, double-Ca2+, recognition site for phosphoserine that may serve as a phosphatidylserine, receptor site in vivo.

About this StructureAbout this Structure

1A8B is a Single protein structure of sequence from Rattus norvegicus with CA and GPE as ligands. Structure known Active Site: GPE. Full crystallographic information is available from OCA.

ReferenceReference

Ca(2+)-bridging mechanism and phospholipid head group recognition in the membrane-binding protein annexin V., Swairjo MA, Concha NO, Kaetzel MA, Dedman JR, Seaton BA, Nat Struct Biol. 1995 Nov;2(11):968-74. PMID:7583670

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	[[Category: phospholipid analog]]		[[Category: phospholipid analog]]

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