4fki: Difference between revisions
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==Crystal Structure of the Cdk2 in Complex with Aminopyrazole Inhibitor== | ==Crystal Structure of the Cdk2 in Complex with Aminopyrazole Inhibitor== | ||
<StructureSection load='4fki' size='340' side='right' caption='[[4fki]], [[Resolution|resolution]] 1.60Å' scene=''> | <StructureSection load='4fki' size='340' side='right' caption='[[4fki]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4fki]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[4fki]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FKI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FKI FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=09K:N-(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)-2-[4-(TRIFLUOROMETHOXY)PHENYL]ACETAMIDE'>09K</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=09K:N-(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)-2-[4-(TRIFLUOROMETHOXY)PHENYL]ACETAMIDE'>09K</scene></td></tr> | ||
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr> | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ek3|4ek3]], [[4ek4|4ek4]], [[4ek5|4ek5]], [[4ek6|4ek6]], [[4ek8|4ek8]], [[4fkg|4fkg]], [[4fkj|4fkj]], [[4fkl|4fkl]], [[4fko|4fko]], [[4fkp|4fkp]], [[4fkr|4fkr]], [[4fks|4fks]], [[4fkt|4fkt]], [[4fku|4fku]], [[4fkv|4fkv]], [[4fkw|4fkw]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ek3|4ek3]], [[4ek4|4ek4]], [[4ek5|4ek5]], [[4ek6|4ek6]], [[4ek8|4ek8]], [[4fkg|4fkg]], [[4fkj|4fkj]], [[4fkl|4fkl]], [[4fko|4fko]], [[4fkp|4fkp]], [[4fkr|4fkr]], [[4fks|4fks]], [[4fkt|4fkt]], [[4fku|4fku]], [[4fkv|4fkv]], [[4fkw|4fkw]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CDK2, CDKN2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CDK2, CDKN2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fki OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fki RCSB], [http://www.ebi.ac.uk/pdbsum/4fki PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fki OCA], [http://pdbe.org/4fki PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fki RCSB], [http://www.ebi.ac.uk/pdbsum/4fki PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fki ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
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==See Also== | ==See Also== | ||
*[[ | *[[Cyclin-dependent kinase|Cyclin-dependent kinase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Cyclin-dependent kinase]] | [[Category: Cyclin-dependent kinase]] | ||
[[Category: | [[Category: Human]] | ||
[[Category: Kang, Y N]] | [[Category: Kang, Y N]] | ||
[[Category: Stuckey, J A]] | [[Category: Stuckey, J A]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
[[Category: Transferase-transferase inhibitor complex]] | [[Category: Transferase-transferase inhibitor complex]] |