1crf: Difference between revisions
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<StructureSection load='1crf' size='340' side='right' caption='[[1crf]], [[NMR_Ensembles_of_Models | 12 NMR models]]' scene=''> | <StructureSection load='1crf' size='340' side='right' caption='[[1crf]], [[NMR_Ensembles_of_Models | 12 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1crf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[1crf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chinese_cobra Chinese cobra]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CRF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CRF FirstGlance]. <br> | ||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1cre|1cre]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1cre|1cre]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1crf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1crf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1crf RCSB], [http://www.ebi.ac.uk/pdbsum/1crf PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1crf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1crf OCA], [http://pdbe.org/1crf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1crf RCSB], [http://www.ebi.ac.uk/pdbsum/1crf PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/3SA2_NAJAT 3SA2_NAJAT]] Basic protein that binds to cell membrane and depolarizes cardiomyocytes. It also shows lytic activities, but 2-fold less important than that of CTX-A4. It binds to the integrin alpha-V/beta-3 (ITGAV/ITGB3) with a moderate affinity. It may interact with sulfatides in the cell membrane which induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes. It also may target the mitochondrial membrane and induce mitochondrial swelling and fragmentation.<ref>PMID:9398182</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 1crf" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Chinese cobra]] | ||
[[Category: Bhaskaran, R]] | [[Category: Bhaskaran, R]] | ||
[[Category: Chang, K D]] | [[Category: Chang, K D]] | ||