1du1: Difference between revisions
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1du1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1du1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1du1 RCSB], [http://www.ebi.ac.uk/pdbsum/1du1 PDBsum]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1du1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1du1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1du1 RCSB], [http://www.ebi.ac.uk/pdbsum/1du1 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/CAC1S_RABIT CAC1S_RABIT]] Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle. | |||
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== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||