1sij: Difference between revisions
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|PDB= 1sij |SIZE=350|CAPTION= <scene name='initialview01'>1sij</scene>, resolution 2.30Å | |PDB= 1sij |SIZE=350|CAPTION= <scene name='initialview01'>1sij</scene>, resolution 2.30Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand= | |LIGAND= <scene name='pdbligand=AST:ARSENITE'>AST</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PCD:(MOLYBDOPTERIN-CYTOSINE+DINUCLEOTIDE-S,S)-DIOXO-AQUA-MOLYBDENUM(V)'>PCD</scene> | ||
|ACTIVITY= [http://en.wikipedia.org/wiki/Aldehyde_oxidase Aldehyde oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.3.1 1.2.3.1] | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Aldehyde_oxidase Aldehyde oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.3.1 1.2.3.1] </span> | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY=[[1hlr|1HLR]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sij OCA], [http://www.ebi.ac.uk/pdbsum/1sij PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1sij RCSB]</span> | |||
}} | }} | ||
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[[Category: Romao, M J.]] | [[Category: Romao, M J.]] | ||
[[Category: Thapper, A.]] | [[Category: Thapper, A.]] | ||
[[Category: | [[Category: aldehyde oxidoreductase]] | ||
[[Category: | [[Category: arsenite inhibition]] | ||
[[Category: | [[Category: xanthine oxidase family]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:42:31 2008'' | ||
Revision as of 23:42, 30 March 2008
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| , resolution 2.30Å | |||||||
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| Ligands: | , , , , | ||||||
| Activity: | Aldehyde oxidase, with EC number 1.2.3.1 | ||||||
| Related: | 1HLR
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of the Aldehyde Dehydrogenase (a.k.a. AOR or MOP) of Desulfovibrio gigas covalently bound to [AsO3]-
OverviewOverview
X-ray crystallography has been used to determine the structure of arsenite-inhibited aldehyde dehydrogenase from Desulfovibrio gigas, a member of the xanthine oxidase family of mononuclear molybdenum enzymes. The structure shows an AsO3 moiety bound to the molybdenum atom of the active site through one of the oxygen atoms. A reduced sample of arsenite-inhibited aldehyde dehydrogenase has a Mo(V) signal that shows anisotropic hyperfine and quadrupole coupling to one arsenic atom. This signal has a strong resemblance with a previously reported signal for arsenite-inhibited xanthine oxidase.
About this StructureAbout this Structure
1SIJ is a Single protein structure of sequence from Desulfovibrio gigas. Full crystallographic information is available from OCA.
ReferenceReference
X-ray crystal structure and EPR spectra of "arsenite-inhibited" Desulfovibriogigas aldehyde dehydrogenase: a member of the xanthine oxidase family., Boer DR, Thapper A, Brondino CD, Romao MJ, Moura JJ, J Am Chem Soc. 2004 Jul 21;126(28):8614-5. PMID:15250689
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