Human lactoferrin: Difference between revisions
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The structure of LF<sub>N</sub> undergoes a dramatic conformational change upon iron binding. Upon iron binding, the two domains of LF<sub>N</sub> undergo a rigid 54.1º rotation about a <scene name='Sandbox_Reserved_302/Hinge/1'>screw axis</scene> that passes through Thr90 and Pro251.<ref name="gerstein">PMID:8230220</ref> | The structure of LF<sub>N</sub> undergoes a dramatic conformational change upon iron binding. Upon iron binding, the two domains of LF<sub>N</sub> undergo a rigid 54.1º rotation about a <scene name='Sandbox_Reserved_302/Hinge/1'>screw axis</scene> that passes through Thr90 and Pro251.<ref name="gerstein">PMID:8230220</ref> | ||
<jmol> | |||
<jmolLink> | |||
<script>load files "=1CB6" "=1LCF";model 0;cartoon only;domain2 = {(92-249 or 1092-1249)}; | |||
structures = [{1.1}, {2.1}]; | |||
domains = [[{not domain2},{not domain2}, {alpha and not domain2 and not %B}], [{domain2}, {(91,1091,250,1250) and *.CA}, {alpha and domain2 and not %B}],]; | |||
script "https://proteopedia.org/wiki/images/a/a2/Storymorph.spt";model 1;delay 0.5;model 2;delay 0.5;model 1; | |||
</script> | |||
<text>domain motion</text> | |||
</jmolLink> | |||
</jmol> | |||
<jmol> | |||
<jmolButton> | |||
<script>morph_palindrome = 1; | |||
morph(15,structures,domains)</script> | |||
<text>Morph</text> | |||
</jmolButton> | |||
</jmol> | |||
=Function & Application= | =Function & Application= | ||