4hk4: Difference between revisions

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hk4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hk4 RCSB], [http://www.ebi.ac.uk/pdbsum/4hk4 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hk4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hk4 RCSB], [http://www.ebi.ac.uk/pdbsum/4hk4 PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/SYY_METJA SYY_METJA]] Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).<ref>PMID:10585437</ref> 


==See Also==
==See Also==
*[[Aminoacyl tRNA Synthetase|Aminoacyl tRNA Synthetase]]
*[[Aminoacyl tRNA Synthetase|Aminoacyl tRNA Synthetase]]
== References ==
<references/>
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Revision as of 20:22, 25 December 2014

Crystal structure of apo Tyrosine-tRNA ligase mutant proteinCrystal structure of apo Tyrosine-tRNA ligase mutant protein

Structural highlights

4hk4 is a 1 chain structure with sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Gene:tyrS, MJ0389 (Methanocaldococcus jannaschii)
Activity:Tyrosine--tRNA ligase, with EC number 6.1.1.1
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[SYY_METJA] Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).[1]

See Also

References

  1. Steer BA, Schimmel P. Major anticodon-binding region missing from an archaebacterial tRNA synthetase. J Biol Chem. 1999 Dec 10;274(50):35601-6. PMID:10585437

4hk4, resolution 2.30Å

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