1rzf: Difference between revisions
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|PDB= 1rzf |SIZE=350|CAPTION= <scene name='initialview01'>1rzf</scene>, resolution 1.70Å | |PDB= 1rzf |SIZE=350|CAPTION= <scene name='initialview01'>1rzf</scene>, resolution 1.70Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene> | |LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY=[[1rz7|1RZ7]], [[1rz8|1RZ8]], [[1rzg|1RZG]], [[1rzi|1RZI]], [[1rzj|1RZJ]], [[1rzk|1RZK]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rzf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rzf OCA], [http://www.ebi.ac.uk/pdbsum/1rzf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rzf RCSB]</span> | |||
}} | }} | ||
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[[Category: Wyatt, R.]] | [[Category: Wyatt, R.]] | ||
[[Category: Zhang, M Y.]] | [[Category: Zhang, M Y.]] | ||
[[Category: | [[Category: antibody]] | ||
[[Category: | [[Category: cd4i]] | ||
[[Category: hiv-1 | [[Category: gp120]] | ||
[[Category: hiv-1]] | |||
[[Category: tyrosine sulfation]] | |||
[[Category: vh-gene usage]] | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:35:10 2008'' | ||
Revision as of 23:35, 30 March 2008
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| , resolution 1.70Å | |||||||
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| Ligands: | , | ||||||
| Related: | 1RZ7, 1RZ8, 1RZG, 1RZI, 1RZJ, 1RZK
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of Human anti-HIV-1 GP120-reactive antibody E51
OverviewOverview
The conserved surface of the HIV-1 gp120 envelope glycoprotein that binds to the HIV-1 coreceptor is protected from humoral recognition by multiple layers of camouflage. Here we present sequence and genomic analyses for 12 antibodies that pierce these defenses and determine the crystal structures of 5. The data reveal mechanisms and atomic-level details for three unusual immune features: posttranslational mimicry of coreceptor by tyrosine sulfation of antibody, an alternative molecular mechanism controlling such sulfation, and highly selective V(H)-gene usage. When confronted by extraordinary viral defenses, the immune system unveils novel adaptive capabilities, with tyrosine sulfation enhancing the vocabulary of antigen recognition.
About this StructureAbout this Structure
1RZF is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120., Huang CC, Venturi M, Majeed S, Moore MJ, Phogat S, Zhang MY, Dimitrov DS, Hendrickson WA, Robinson J, Sodroski J, Wyatt R, Choe H, Farzan M, Kwong PD, Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2706-11. Epub 2004 Feb 23. PMID:14981267
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